Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a

中文名稱：

Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a
貨號：

CSB-YP350809PSZ
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a
貨號：

CSB-EP350809PSZ
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a
貨號：

CSB-EP350809PSZ-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a
貨號：

CSB-BP350809PSZ
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Psalmopoeus cambridgei Pi-theraphotoxin-Pc1a
貨號：

CSB-MP350809PSZ
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

P60514
別名：

; Psalmotoxin-1; PcTx1; Pi-theraphotoxin-Pc1a; Pi-TRTX-Pc1a
種屬：

Psalmopoeus cambridgei (Trinidad chevron tarantula)
蛋白長度：

Cytoplasmic domain
表達區域：

1-40
氨基酸序列

EDCIPKWKGC VNRHGDCCEG LECWKRRRSF EVCVPKTPKT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

This toxin is a gating modifier that acts principally as an inhibitor on ASIC1a (ASIC isoform 2) and a potentiator on ASIC1b (ASIC isoform 3). This toxin potently and selectively inhibits rat, mouse and human ASIC1a (IC(50)=0.35-3.7 nM). The blockade is rapidly reversible. The toxin acts by shifting its steady-state desensitization to more alkaline pH (0.27 pH unit). At higher concentrations, it potentiates rat and human ASIC1b and activates chicken ASIC1 by stabilizing the open state of these subtypes. The toxin binds most tightly to the open and the desensitized states of ASIC1a (promoting desensitization), whereas it binds most tightly to the open state of ASIC1b (promoting opening). The toxin also inhibits mouse ASIC1a-ASIC2b (IC(50)=2.64 nM) and rat ASIC1a-ASIC2a. It binds to the extracellular domain at subunit interfaces in the acidic pocket with the majority of contacts on the thumb domain of the channel. It is also noteworthy that calcium competes with the toxin, probably by inhibiting binding of the toxin to the channel.
亞細胞定位：

Secreted.
蛋白家族：

Psalmotoxin-1 family
組織特異性：

Expressed by the venom gland.