Recombinant Protein maternal effect lethal 26 (mel-26)

中文名稱：

秀麗隱桿線蟲mel-26重組蛋白
貨號：

CSB-YP856698CXY
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲mel-26重組蛋白
貨號：

CSB-EP856698CXY
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲mel-26重組蛋白
貨號：

CSB-EP856698CXY-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲mel-26重組蛋白
貨號：

CSB-BP856698CXY
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲mel-26重組蛋白
貨號：

CSB-MP856698CXY
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

mel-26
Uniprot No.：

Q94420
別名：

mel-26; ZK858.4Protein maternal effect lethal 26
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-395
氨基酸序列

MEPRIDGGVF IGGIGNSGNE MCSNGVPALG VSSQTEIKVE KVQHTWTVKN FSHCYQEYLE NFVYLQRGDE QLTWSIKIYP KGNGENNKDF VFLCLNRVIN NNVKAGKIGF KSQFKLRTAE NKDIEMRIHP NPSHSDYVSY IKRDVLFPQI MPRDMIIVNV EIDVAVETIT TTNEPIQFEP TNSEQQLIED YQRLFSQELL CDFAINVNGK IIRAHKAVLA ARSPVFNAML THQDTDEAKS SMMYINDMDY DVIYEMVYYI YCGRCNKDIT DMATALLIAA DKYRLEELKS HCEKYLVENI NIENACSLLI IGDLYSAPKL RKRAVTYILA RPKNVTGTPG WEDILKGHPN LITDIFSQID RQSSTGATSS VSNLPGVPMD IPGITGNIVP PPSGL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway.
基因功能參考文獻：
1. KLHL22 plays a conserved role to mediate the activation of mTORC1 and downstream events in mammals and nematodes; depletion of MEL-26, the Caenorhabditis elegans orthologue of KLHL22, extends worm lifespan PMID: 29769719
2. the identification of a large family of BTB-domain protein MEL-26 and its genetic target MEI-1 as substrate-specific adaptors for C. elegans CUL-3 PMID: 13679922
3. MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism. PMID: 16169482
4. KO8F11.3 regulates mel-26 in the helminth embryo. PMID: 17403899
5. FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis. PMID: 17878235
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亞細胞定位：

Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, I band.
組織特異性：

Expressed in body wall muscles.
數據庫鏈接：

STRING: 6239.ZK858.4

UniGene: Cel.5086