Recombinant Protein lin-41 (lin-41), partial

中文名稱：

秀麗隱桿線蟲lin-41重組蛋白
貨號(hào)：

CSB-YP866175CXY
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲lin-41重組蛋白
貨號(hào)：

CSB-EP866175CXY
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲lin-41重組蛋白
貨號(hào)：

CSB-EP866175CXY-B
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲lin-41重組蛋白
貨號(hào)：

CSB-BP866175CXY
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲lin-41重組蛋白
貨號(hào)：

CSB-MP866175CXY
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

lin-41
Uniprot No.：

Q9U489
別名：

lin-41; C12C8.3Protein lin-41; Abnormal cell lineage protein 41
種屬：

Caenorhabditis elegans
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repression of translation. Degrades the mRNA of transcription factor dmd-3 to govern the timing and extent of male tail tip morphogenesis. Plays a role in the sexual maturation of the nervous system.
基因功能參考文獻(xiàn)：
1. LIN-41 represses translation of spn-4 and meg-1during oocyte meiotic maturation and the oocyte-to-embryo transition. PMID: 28576864
2. Study reports that the stem cell fate regulator LIN41 silences mRNAs through two distinct and separable mechanisms: translational repression or degradation. Choice of mechanism is specified by the location of the LIN41- binding site on the target mRNA. PMID: 28111013
3. Lin-41 regulates the gene expression required for timely centrosome elimination around the diplotene stage in female germ cells. PMID: 26764090
4. regulation of LIN-41 alone is necessary and sufficient to prevent vulval rupturing. Hence, let-7 does not function to reduce gene expression noise broadly, but to direct vulval development through extensive regulation of a single, defined target PMID: 25669883
5. LIN-41 appears to function in the germline and the soma via different molecular mechanisms PMID: 25167051
6. In older anterior ventral microtubule axons, let-7inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promotingfactor. PMID: 23599497
7. NMR structure reveals details of the binding of let-7 miRNA to lin-41 mRNA which involves formation of a complex with non-canonical structural elements within the seed region. PMID: 20660479
8. lin-41, a homologue of the vertebtate lin-41, functions as a heterochronic gene. PMID: 16477647
9. two novel, gain-of-function alleles of lin-41. Small changes affecting LIN-41 could have been significant for male tail evolution.lin-41 governs the timing and extent of male tail tip morphogenesis in a dose-dependent manner. PMID: 16806150
10. NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site in the 3' untranslated region of the lin-41 mRNA. PMID: 18296482
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亞細(xì)胞定位：

Cytoplasm. Cytoplasm, P-body.
蛋白家族：

TRIM/RBCC family
數(shù)據(jù)庫(kù)鏈接：

KEGG: cel:CELE_C12C8.3

STRING: 6239.C12C8.3a.1

UniGene: Cel.5222