Recombinant Mouse Zinc fingers and homeoboxes protein 2 (Zhx2), partial

中文名稱：

小鼠Zhx2重組蛋白
貨號：

CSB-YP805376MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Zhx2重組蛋白
貨號：

CSB-EP805376MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Zhx2重組蛋白
貨號：

CSB-EP805376MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Zhx2重組蛋白
貨號：

CSB-BP805376MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Zhx2重組蛋白
貨號：

CSB-MP805376MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Zhx2
Uniprot No.：

Q8C0C0
別名：

Zhx2; Afr1; Raf; Zinc fingers and homeoboxes protein 2; Alpha-fetoprotein regulator 1; AFP regulator 1; Regulator of AFP; Zinc finger and homeodomain protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
基因功能參考文獻：
1. Additional Cyp genes are disregulated in the absence of Zhx2. PMID: 27197076
2. Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes PMID: 28258223
3. NFAT1 protein activation can shift oncogenic Ras/Raf/MEK/ERK signaling to acting as a tumor suppressor pathway. PMID: 23583303
4. The Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase, a gene normally silenced in the adult liver. PMID: 20160197
5. Zhx2 acts as a repressor of Gpc3 in the adult liver. PMID: 17668883
6. The carboxyl terminus of Angptl4 alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf/MEK/ERK1/2 MAP kinase pathway in endothelial cells. PMID: 18340008
7. These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis. PMID: 19470390
8. evidence presented that ZHX2 & ephrin-B1 cytoplasmic domain can interact & regulate transcription; study identifies ZHX2 as novel regulator of neural progenitor cell maintenance & suggests potential nuclear mechanism of ephrin-B function in the cortex PMID: 19515908
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亞細胞定位：

Nucleus.
蛋白家族：

ZHX family
組織特異性：

Expressed in retina where it localizes to Muller glial cells of the inner nuclear layer (at protein level). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
數據庫鏈接：

KEGG: mmu:387609

STRING: 10090.ENSMUSP00000094164

UniGene: Mm.36557