Recombinant Mouse Zinc finger protein ZFPM2 (Zfpm2), partial

中文名稱：

小鼠Zfpm2重組蛋白
貨號：

CSB-YP804019MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Zfpm2重組蛋白
貨號：

CSB-EP804019MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Zfpm2重組蛋白
貨號：

CSB-EP804019MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Zfpm2重組蛋白
貨號：

CSB-BP804019MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Zfpm2重組蛋白
貨號：

CSB-MP804019MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Zfpm2
Uniprot No.：

Q8CCH7
別名：

Zfpm2; Fog2Zinc finger protein ZFPM2; Friend of GATA protein 2; FOG-2; Friend of GATA 2; mFOG-2; Zinc finger protein multitype 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
基因功能參考文獻：
1. Fog2Rb-/Rb- mice are resistant to obesity and present abnormal WAT/BAT conversion. PMID: 29262331
2. identified key controls over corticothalamic projection neurons (CThPN) development and identify Fog2 as a critical control over CThPN diversity PMID: 27321927
3. FOG2 liver-specific knockout mice they exhibit enhanced insulin sensitivity and elevated hepatic TG accumulation, which were also reversed by Ad-PPARalpha. The results demonstrate a novel function of hepatic FOG2 in insulin sensitivity and lipid metabolism through PPARalpha. PMID: 27207553
4. Hypoxia-induced microRNA-429 promotes differentiation of osteoblastic cells by mediating ZFPM2 expression. PMID: 27576955
5. MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression PMID: 26285119
6. Results indicate that FOG-2/NuRD interaction is required for cardiomyocyte proliferation. PMID: 25196150
7. ATOH8, GATA4, and FOG2 associate in a single complex PMID: 23836893
8. regulation of ovarian differentiation is dependent upon GATA4 but not FOG2 PMID: 23769843
9. a new dynamics in which GATA-4 may alter the activity of FOG-2 by influencing its SUMOylation status PMID: 23226341
10. gonadal loss of Fog2 resulted in an early partial block in male pathway and sex reversal PMID: 21385577
11. FOG-2 null mouse embryos had thin compact myocardium, higher EDP and E/A ratio, smaller -dP/dt, and decreased sucking pressure than wild littermates, indicating that decreased ventricular diastolic function might be the main cause of embryonic lethality PMID: 14551244
12. the N-terminal domain of FOG2 has a role in mediating transcriptional repression PMID: 15507435
13. A Fog2-Gata4 interaction is critical for the development of normal pulmonary lobar structure, and this phenotype is not influenced by the additional loss of Gata6 interaction. PMID: 17142311
14. FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. PMID: 17274974
15. implicates FOG2 in the maintenance of epithelial cell differentiation in the mammary gland and in performing a protective role in breast cancer PMID: 17310981
16. Results suggest that FOG-2 repressive activity may be modulated by the generation of isoforms of FOG-2 lacking the FOG repression motif. PMID: 17445768
17. Fog2 transcription factors are haploinsufficient for testis determination in mice PMID: 17848526
18. the Lhx9 gene represents the first direct target of the GATA4/FOG2 repressor complex in cardiac development. PMID: 18577233
19. SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling PMID: 18658259
20. Control of ovarian development by the GATA4-FOG2 complex presents a novel insight into the cross-talk between transcriptional regulation and extracellular signaling that occurs in ovarian development PMID: 18927154
21. FOG2 regulates adult heart function and coronary angiogenesis PMID: 19411759
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亞細胞定位：

Nucleus.
蛋白家族：

FOG (Friend of GATA) family
組織特異性：

Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in t
數(shù)據(jù)庫鏈接：

KEGG: mmu:22762

STRING: 10090.ENSMUSP00000051335

UniGene: Mm.39496