Recombinant Mouse WD repeat domain phosphoinositide-interacting protein 4 (Wdr45)

中文名稱：

小鼠Wdr45重組蛋白
貨號：

CSB-YP852773MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Wdr45重組蛋白
貨號：

CSB-EP852773MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Wdr45重組蛋白
貨號：

CSB-EP852773MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Wdr45重組蛋白
貨號：

CSB-BP852773MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Wdr45重組蛋白
貨號：

CSB-MP852773MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Wdr45
Uniprot No.：

Q91VM3
別名：

Wdr45; DXImx38e; Wdrx1; Wipi4; WD repeat domain phosphoinositide-interacting protein 4; WIPI-4; WD repeat domain X-linked 1; WD repeat-containing protein 45
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-360
氨基酸序列

MTQQPLRGVT SLHFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS VGLVEMLHRS NLLALVGGGS SPKFSEISVL IWDDAREGKD SKDKLVLEFT FTKPVLAVRM RHDKIVIVLR NRIYVYSFPD SPRKLFEFDT RDNPKGLCDL CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG TSSAPFTINA HQSDVACVSL NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL YCINFSHDSS FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV YLDICDDEDF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.
基因功能參考文獻：
1. Nes-Wdr45(fl/Y) mice recapitulate some hallmarks of beta-propeller protein-associated neurodegeneration, including cognitive impairment and defective axonal homeostasis PMID: 26000824
亞細胞定位：

Preautophagosomal structure. Cytoplasm.
蛋白家族：

WD repeat SVP1 family
數據庫鏈接：

KEGG: mmu:54636

STRING: 10090.ENSMUSP00000041456

UniGene: Mm.305725