Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1 (Cacnb1)

中文名稱：

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1(Cacnb1)
貨號：

CSB-YP854513MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1(Cacnb1)
貨號：

CSB-EP854513MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1(Cacnb1)
貨號：

CSB-EP854513MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1(Cacnb1)
貨號：

CSB-BP854513MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-1(Cacnb1)
貨號：

CSB-MP854513MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cacnb1
Uniprot No.：

Q8R3Z5
別名：

Cacnb1; Cacnlb1Voltage-dependent L-type calcium channel subunit beta-1; CAB1; Calcium channel voltage-dependent subunit beta 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-597
氨基酸序列

MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR LSSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLDRATG EHASVHEYPG ELGQPPGLYP SNHPLGRAGT LRALSRQDTF DADTPGSRNS AYTEPGDSCV DMETDPSEGP GPGDPAGGGT PPARQGSWED EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYTR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
基因功能參考文獻：
1. Structural and biophysical analyses of the skeletal dihydropyridine receptor beta subunit beta1a reveal critical roles of domain interactions for stability. PMID: 28351836
2. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of beta1a and RyR1 in resting myotubes. PMID: 26114725
3. TnT3 facilitates Cavbeta1a nuclear recruitment, suggesting that the two proteins play a heretofore unknown role during early muscle differentiation in addition to their classical role in excitation-contraction coupling regulation. PMID: 25981458
4. The motif Leu(496)-Leu(500)-Trp(503) within the bet1a C-terminal tail plays a nonessential role in the bidirectional DHPR/RyR1 signaling that supports skeletal-type excitation-contraction coupling. PMID: 25384984
5. Cavbeta1a acts as a Cav-independent regulator of gene expression in MPCs, and is required for their normal expansion during myogenic development. PMID: 24934157
6. Data suggest that specific hydrophobic surface residues in calcium channel voltage-dependent beta1a subunit C-terminus bind to RyR1 and increase channel activity in lipid bilayers and thus may support skeletal muscle excitation-contraction coupling. PMID: 22962299
7. Cavbeta1 is predominantly expressed in the strata oriens and radiatum of the hippocampus, and only weakly in the cerebellum, in the developing mouse brain. PMID: 22737983
8. The results of this study indicated that the skeletal muscle DHPR retrogradely regulates the patterning and formation of the Neuromuscular junction. PMID: 21441923
9. Mice with cardiac-specific sequestration of the beta-subunit of the L-type calcium channel PMID: 12054671
10. calcium channel beta1a subunits are organized in triad junctions in skeletal muscle PMID: 16317008
11. excitation-contraction coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR, namely alpha1S and beta1a, interacting with possibly different domains of RyR1 [DHPR beta1a] PMID: 16357209
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亞細胞定位：

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.
蛋白家族：

Calcium channel beta subunit family
組織特異性：

Detected in the inner nuclear layer in the retina (at protein level). Detected in skeletal muscle, brain, heart and spleen.
數據庫鏈接：

KEGG: mmu:12295

STRING: 10090.ENSMUSP00000017552

UniGene: Mm.41252