Recombinant Mouse V-type proton ATPase subunit d 2 (Atp6v0d2)

中文名稱：

Recombinant Mouse V-type proton ATPase subunit d 2(Atp6v0d2)
貨號：

CSB-YP770449MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse V-type proton ATPase subunit d 2(Atp6v0d2)
貨號：

CSB-EP770449MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse V-type proton ATPase subunit d 2(Atp6v0d2)
貨號：

CSB-EP770449MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse V-type proton ATPase subunit d 2(Atp6v0d2)
貨號：

CSB-BP770449MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse V-type proton ATPase subunit d 2(Atp6v0d2)
貨號：

CSB-MP770449MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Atp6v0d2
Uniprot No.：

Q80SY3
別名：

Atp6v0d2; V-type proton ATPase subunit d 2; V-ATPase subunit d 2; Osteoclast-specific vacuolar ATP synthase; Vacuolar proton pump subunit d 2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-350
氨基酸序列

MLETAELYFN VDHGYLEGLV RGCKASLLTQ QDYVNLVQCE TLEDLKIHLQ TTDYGNFLAN ETNPLTVSKI DTEMRKKLCR EFDYFRNHSL EPLSTFLTYM TCSYMIDNII LLMNGALQKK SVKEVLAKCH PLGRFTEMEA VNIAETPSDL FKAVLVETPL APFFQDCMSE NTLDELNIEL LRNKLYKSYL EAFYKFCKDH GDVTADVMCP ILEFEADRRA LIITLNSFGT ELSKEDRETL FPTCGRLYPE GLRLLAQAED FEQMKRVADN YGVYKPLFDA VGGSGGKTLE DVFYEREVQM NVLAFNRQFH YGVFYAYVKL KEQEMRNIVW IAECISQRHR TKINSYIPIL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.
基因功能參考文獻：
1. High V-ATPase expression is associated with Bone Pain Induced by Multiple Myeloma. PMID: 28254863
2. we propose that PTH has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling PMID: 26647715
3. Insulin significantly activated ERK1/2 MAP kinase as well as markedly induced the expression of NFATc1, an osteoclast marker gene, and Atp6v0d2, an osteoclast fusion-related gene. PMID: 26343857
4. V-ATPase has a role in modulating a macrophage phenotype towards tumor-associated macrophages through the action of the a2 isoform of V-ATPase PMID: 24362525
5. Luteolin can be effective in reducing bone resorption and that this effect of luteolin may be through disruption of osteoclast V-ATPase a3-d2 interaction. PMID: 23129004
6. PKCdelta deficiency does not perturb formation of the ruffled border or trafficking of lysosomal vesicles containing the vacuolar-ATPase (v-ATPase). PMID: 22806935
7. these findings suggest that the critical role of ATP6v0d2 may be limited to the control of bone homeostasis under normal development. PMID: 21040703
8. The data indicate that integrity of lipid rafts regulates the activity of V-ATPase in osteoclasts, suggesting that cholesterol-lowering agents might be useful for inhibiting osteoclast-dependent bone resorption. PMID: 20127130
9. d2 is expressed mainly in kidney and at lower levels in heart, spleen, skeletal muscle, and testis. The d2 isoform can complement the yeast vma6Delta phenotype when cells are grown at 25, but not 30, degrees C. PMID: 12963731
10. d2 mRNA and protein appear later during nephrogenesis than does the ubiquitously expressed E1 subunit PMID: 15800125
11. d2 protein displayed association with membranes and the localization in lysosomes and antigen-containing endosomes. PMID: 16144709
12. Atp6v0d2 is a regulator of osteoclast fusion and bone formation. PMID: 17128270
13. Data indicate for the first time that the NFATc1/Atp6v0d2 and DC-STAMP signaling axis plays a key role in the osteoclast multinucleation process, which is essential for efficient bone resorption. PMID: 17885208
14. Atp6v0d2 (d2), an isoform of the d subunit in the V-ATPase, showed 5-fold higher expression than that of Atp6v0d1 (d1) in mature osteoclasts, indicating a potential function in osteoclastic bone resorption. PMID: 19113919
15. MEF2 and MITF function cooperatively with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis. PMID: 19321441
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蛋白家族：

V-ATPase V0D/AC39 subunit family
組織特異性：

Predominantly expressed in the kidney. Also expressed in the lung, testis, skeletal muscle and heart. Upr-egulated during osteoclast differentiation and is most abundant in mature osteoclasts.
數據庫鏈接：

KEGG: mmu:242341

STRING: 10090.ENSMUSP00000029900

UniGene: Mm.19298