Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 19 (Usp19), partial

中文名稱(chēng)：

小鼠Usp19重組蛋白
貨號(hào)：

CSB-YP662372MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

小鼠Usp19重組蛋白
貨號(hào)：

CSB-EP662372MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

小鼠Usp19重組蛋白
貨號(hào)：

CSB-EP662372MO-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

小鼠Usp19重組蛋白
貨號(hào)：

CSB-BP662372MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

小鼠Usp19重組蛋白
貨號(hào)：

CSB-MP662372MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Usp19
Uniprot No.：

Q3UJD6
別名：

Usp19; Kiaa0891; Ubiquitin carboxyl-terminal hydrolase 19; EC 3.4.19.12; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
基因功能參考文獻(xiàn)：
1. Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta) PMID: 28886438
2. Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles PMID: 26048142
3. Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling. PMID: 25568336
4. Data suggest that, in young female mice, 17beta-estradiol upregulates USP19 expression through Esr1 (estrogen receptor alpha) and leads to down-regulation of muscle mass and down-regulation of ubiquitination of muscle proteins. PMID: 25901042
5. E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression. PMID: 21971047
6. study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation PMID: 19015242
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亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:71472

STRING: 10090.ENSMUSP00000006854

UniGene: Mm.289706