1. Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells. PMID: 29845271
2. Results indicate spleen tyrosine kinase (SYK) as an essential mediator of brown fat formation and function. PMID: 29235464
3. CD11b promotes the differentiation of osteoclasts induced by RANKL through the Syk signaling pathway. PMID: 28661042
4. Phosphorylation levels of 10 phosphosites in spleen tyrosine kinase (SYK) were increased following B cell receptor activation. 4 cluster regions, encompassing 8 phosphosites, were activated by mercury. Phosphorylation of tyrosine-342 and -346 residues were most sensitive to mercury exposure. PMID: 28716125
5. Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy. PMID: 28919467
6. Syk kinase acts downstream of receptors controlling granule cells tangential migration PMID: 28768156
7. Results show that Syk activation occurs following Abeta deposition and the formation of tau pathological species. As Syk activation also promotes Abeta formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease. PMID: 28877763
8. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
9. Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR-proximal signals. PMID: 28760774
10. SYK could induce HO-1 expression by regulating the Akt phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment. PMID: 28869869
11. These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita PMID: 28576735
12. Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana. PMID: 28830213
13. The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis. PMID: 27559049
14. ephrin B3/EphB2 are obvious candidates for driving the Syk-dependent repulsive response. PMID: 27122172
15. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 inflammasome-dependent IL-1beta production in macrophages. PMID: 27365531
16. The effect of Smad4 was at least partially mediated by the downstream effectors Syk and ROCK2 transcription in megakaryocytes. PMID: 28663280
17. Gene expression analysis of lung tissues revealed that HDM-induced expression of IL-17 and CXCL-1 was significantly attenuated in both Sykdel/del and GSK143-treated mice. CONCLUSION: Syk inhibitors may play a role in the management of neutrophilic asthma PMID: 28107345
18. collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI. PMID: 27505889
19. Pharmacological Syk inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and to limit infarct progression in acute stroke. PMID: 27102960
20. Studies indicate that SHP1 and SYK crosstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflammation. PMID: 28410990
21. dephosphorylation of Tyr(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation. PMID: 27609517
22. These studies define a pathologic role for myeloid Syk signaling in renal ischemia/reperfusion injury PMID: 27322771
23. Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src/Syk/NF-kappaB and IRAK1/AP-1 signaling. PMID: 27178629
24. Dectin-1 and Dectin-2 seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production PMID: 26297607
25. TNF activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF-induced JNK activation and cell death. PMID: 26212014
26. The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux. PMID: 26970308
27. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye PMID: 26921309
28. Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis. PMID: 26251216
29. results show that cells of neuronal origin adapt their proteome to exogenous alpha-Syn fibrils and actively modify those assemblies PMID: 26708990
30. These results provide new insights into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages. PMID: 25946330
31. Syk mediates airway contractility in the normal and allergic airways, independent of its role and function in leukocytes, and supports a paracrine role for airway epithelial Syk in modulating airway smooth muscle activity. PMID: 25556883
32. Syk expression by DCs is necessary for IL-23p19 production in response to C. albicans PMID: 25033445
33. The Syk inhibitor fostamatinib prevented bleomycin-induced fibrosis and inflammation in the skin and in the lung. The anti-fibrotic effect of fostamatinib is linked to reduced Syk phosphorylation and TGF-beta expression. PMID: 26148346
34. PRT-060318 had a significant, albeit partial, inhibitory effect, thus suggesting that ROS induce NET formation in part via activation of Syk. PMID: 25277753
35. Together these data reveal a mechanism by which SHP-2 mediates the activation of Syk in response to fungal infection. PMID: 25915733
36. These experiments demonstrate that Syk plays a critical role in multiple aspects of B cell antibody responses. PMID: 25862820
37. PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor PMID: 25767114
38. Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-term survival. PMID: 25630702
39. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. PMID: 25430631
40. alphaIIbbeta3 regulates Syk through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk activation and hemITAM phosphorylation by CLEC-2 PMID: 25352128
41. Polyoxygenated cholesterol ester hydroperoxide-induced and TLR4/SYK-mediated macrophage responses may contribute to chronic inflammation in atherosclerosis. PMID: 24376657
42. deregulated Syk activity by itself is not sufficient for the transformation of B cells, as downstream effectors, such as Blimp-1, limit the survival and expansion of the activated B cell PMID: 23955076
43. in DKO pre-B cells, the kinase Zap70 is associated with the pre-BCR, suggesting that Zap70 is important to promote B cell maturation in the absence of Syk and SHP-1. PMID: 24899508
44. Non-receptor protein tyrosine kinase signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia. PMID: 24486434
45. Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI and Syk. PMID: 24023254
46. results demonstrate the opposing regulatory roles of Syk in TLR-mediated TRAF6 and TRAF3 signaling pathways, which suggests that Syk may fine-tune the innate immune response to lessen inflammation. PMID: 23962979
47. Data indicate that ASC was phosphorylated during inflammasome activation in a Syk- and Jnk-dependent manner. PMID: 24185614
48. Syk activates PI3K/Akt signaling which is required for survival of EBV+ B cell lymphomas PMID: 23398911
49. PKCbeta is the isoform responsible for Syk negative regulation PMID: 23960082
50. while the kinase domain of Syk is uniquely required for OC function that of Zap70 inhibits it. PMID: 23494777

顯示更多

收起更多

KEGG: mmu:20963

STRING: 10090.ENSMUSP00000060828

UniGene: Mm.375031