Recombinant Mouse Tumor necrosis factor alpha-induced protein 8-like protein 2 (Tnfaip8l2)

中文名稱：

小鼠Tnfaip8l2重組蛋白
貨號：

CSB-YP875243MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tnfaip8l2重組蛋白
貨號：

CSB-EP875243MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tnfaip8l2重組蛋白
貨號：

CSB-EP875243MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tnfaip8l2重組蛋白
貨號：

CSB-BP875243MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tnfaip8l2重組蛋白
貨號：

CSB-MP875243MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tnfaip8l2
Uniprot No.：

Q9D8Y7
別名：

Tnfaip8l2; Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-184
氨基酸序列

MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRPKAQRVI KDLIKVAVKV AVLHRSGCFG PGELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL VECRDILLEL VEHHLTPKSH DRIRHVFDHY SDPDLLAALY GPDFTQHLGK ICDGLRKLLD EGKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
基因功能參考文獻：
1. TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells. PMID: 29654762
2. TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea. PMID: 29115630
3. Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium. PMID: 29480366
4. the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment..this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. PMID: 28766689
5. TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target. PMID: 29196266
6. Results suggest that tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2) appeared to be a critical immunoregulatory molecule which affected dendritic cells (DCs) maturation and subsequent T-cell mediated immunity. PMID: 27029075
7. The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis. PMID: 29058702
8. TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8(+) T and NK cell-mediated antitumor immune responses PMID: 28314212
9. Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages. PMID: 28122045
10. The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling. PMID: 27601471
11. Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2) gene was down-regulated, the expression of the CD69 antigen was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma were enhanced. PMID: 27363266
12. TIPE2 alleviates experimental SLE through induction of macrophage polarization to a M2 phenotype, which may be used as a promising therapeutic strategy for treating SLE. PMID: 26824452
13. TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses. PMID: 25877863
14. TIPE2 plays a suppressive role in injury-induced restenosis and may serve as a new therapeutic target for treating the disease. PMID: 25912734
15. Tipe2 provides a molecular bridge between miR-21 and cell apoptosis; miR-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2. PMID: 24577093
16. TIPE2 deficiency in hematopoietic cells ameliorates experimental colitis; TIPE2 is a negative regulator of antibacterial immunity, indicating that TIPE2 promotes colitis by inhibiting mucosal immunity to commensal bacteria. PMID: 24973456
17. TIPE2 plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein. PMID: 24081993
18. study reports that TIPE2, the tumor necrosis factor-alpha-induced protein 8-like 2, plays an atheroprotective role by regulating phenotypic switching of vascular smooth muscle cells in response to oxidized low-density lipoprotein stimuli PMID: 23324338
19. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection PMID: 22949657
20. TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia. PMID: 22859306
21. TIPE2 regulates polyinosinic-polycytidylic acid [poly I:C]-induced innate immune responses by targeting Rac GTPase pathways in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. PMID: 22904303
22. The results suggested that TIPE2 appeared to be a critical immunoregulatory molecule involved in immunosuppressive function of CD4(+)CD25(+) Tregs. PMID: 21963221
23. These results indicate that TIPE2 plays an important role in taming Hepatitis B virus-induced hepatic inflammation. PMID: 21466895
24. TIPE2 expression was detected in various murine tissues by immunohistochemistry & RT-PCR. TIPE2 was a cytoplasmic protein expressed preferentially in lymphoid tissues and a small group of non-lymphoid tissues. PMID: 20663561
25. This paper establishes that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis. PMID: 18455983
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蛋白家族：

TNFAIP8 family, TNFAIP8L2 subfamily
組織特異性：

Expressed in thymus, spleen, lymph node and small intestine, but not in liver, heart, muscle, testis, spinal cord or brain. Up-regulated in the spinal cord of mice with experimental autoimmune encephalomyelitis. Constitutively expressed by macrophages, B
數據庫鏈接：

KEGG: mmu:69769

STRING: 10090.ENSMUSP00000013851

UniGene: Mm.34368