Recombinant Mouse Troponin T, fast skeletal muscle (Tnnt3)

中文名稱：

小鼠Tnnt3重組蛋白
貨號(hào)：

CSB-YP874137MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Tnnt3重組蛋白
貨號(hào)：

CSB-EP874137MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Tnnt3重組蛋白
貨號(hào)：

CSB-EP874137MO-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tnnt3重組蛋白
貨號(hào)：

CSB-BP874137MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Tnnt3重組蛋白
貨號(hào)：

CSB-MP874137MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tnnt3
Uniprot No.：

Q9QZ47
別名：

Tnnt3; Troponin T; fast skeletal muscle; TnTf; Fast skeletal muscle troponin T; fTnT
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-272
氨基酸序列

SDEETEQVE EQYEEEEEAQ EEEVQEEAPE PEEVQEDAVA EEEREEDEEE EKPRPKLTAP KIPEGEKVDF DDIQKKRQNK DLMELQALID SHFEARKKEE EELIALKERI EKRRAERAEQ QRIRAEKERE PQNRLAEEKA RREEEDAKRR AEDDMKKKKA LSSMGANYSS YLAKADQKRG KKQTAREMKK KILAERRKPL NIDHLSDDKL RDKAKELWDT LYQLETDKFE FGEKLKRQKY DITTLRSRID QAQKHSKKAG ATAKGKVGGR WK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
基因功能參考文獻(xiàn)：
1. TnT3 regulates expression of Cav1.1 in skeletal muscle, this regulation is impaired in aging. PMID: 28008709
2. TnT3 regulates transcription of Cacna1s, the gene encoding Cav1.1. Knocking down TnT3 in vivo downregulated Cav1.1. PMID: 26892246
3. TnT3 facilitates Cavbeta1a nuclear recruitment, suggesting that the two proteins play a heretofore unknown role during early muscle differentiation in addition to their classical role in excitation-contraction coupling regulation. PMID: 25981458
4. On the basis of these results, it was proposed that aberrant fTnT represents a biological marker of muscle phenotype severity and disease progression. PMID: 24305066
5. Data conclude that TnT3 contains both a nuclear localization signal and a DNA-binding domain, which may mediate nuclear/nucleolar signaling and muscle cell apoptosis. PMID: 23378072
6. fast skeletal muscle troponin activation increases force at submaximal activation in both wildtype and NEB knockout fiber bundles. PMID: 23437068
7. results showed dominantly negative effects of coexistence of fast skeletal muscle TnT and cardiac TnT on contractile kinetics absent the influence of extracellular matrix; a dilatative remodeling at the cellular level was observed, supporting a pathological significance PMID: 22538236
8. The findings suggested that effects of muscle load on Tnnt3 pre-mRNA alternative splicing are controlled by a cell-autonomous mechanism, rather than systemically. PMID: 22592404
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蛋白家族：

Troponin T family
組織特異性：

Expressed predominantly in skeletal muscle.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:21957

STRING: 10090.ENSMUSP00000101578

UniGene: Mm.389992