Recombinant Mouse Tripartite motif-containing protein 2 (Trim2)

中文名稱：

小鼠Trim2重組蛋白
貨號：

CSB-YP880658MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Trim2重組蛋白
貨號：

CSB-EP880658MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Trim2重組蛋白
貨號：

CSB-EP880658MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Trim2重組蛋白
貨號：

CSB-BP880658MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Trim2重組蛋白
貨號：

CSB-MP880658MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Trim2
Uniprot No.：

Q9ESN6
別名：

Trim2; Kiaa0517; Narf; Tripartite motif-containing protein 2; EC 2.3.2.27; E3 ubiquitin-protein ligase TRIM2; Neural activity-related RING finger protein; RING-type E3 ubiquitin transferase TRIM2
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-744
氨基酸序列

MASEGASIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC PVCRQTSILP EKGVAALQNN FFITNLMDVL QRTPGSNGED SSILETVTAV AAGKPLSCPN HDGNVMEFYC QSCETAMCRE CTEGEHAEHP TVPLKDVVEQ HKASLQVQLD AVNKRLPEID SALQFISEII HQLTNQKASI VDDIHSTFDE LQKTLNVRKS VLLMELEVNY GLKHKVLQSQ LDTLLQGQES IKSCSNFTAQ ALNHGTETEV LLVKKQMSEK LNELADQDFP LHPRENDQLD FIVETEGLKK SIHNLGTILT TNAVASETVA TGEGLRQTII GQPMSVTITT KDKDGELCKT GNAYLTAELS TPDGSVADGE ILDNKNGTYE FLYTVQKEGD FTLSLRLYDQ HIRGSPFKLK VIRSADVSPT TEGVKRRVKS PGSGHVKQKA VKRPASMYST GKRKENPIED DLIFRVGTKG RNKGEFTNLQ GVAASTSGKI LIADSNNQCV QIFSNDGQFK SRFGIRGRSP GQLQRPTGVA VHPSGDIIIA DYDNKWVSIF SNDGKFKTKI GSGKLMGPKG VSVDRNGHII VVDNKACCVF IFQPNGKIVT RFGSRGNGDR QFAGPHFAAV NSNNEIIITD FHNHSVKVFN QEGEFMLKFG SNGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDGSG SFLSYINTSA DPLYGPQGLA LTSDGHVVVA DSGNHCFKVY RYLQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
基因功能參考文獻：
1. a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance. PMID: 21478148
2. Trim2 has an important function in the regulation of axon outgrowth during development. PMID: 20796172
3. TRIM2 is an ubiquitin ligase and point to a mechanism regulating neurofilament light subunit metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration PMID: 18687884
亞細胞定位：

Cytoplasm.
蛋白家族：

TRIM/RBCC family
組織特異性：

Highly expressed in the cerebellum, hippocampus, retina and spinal cord. In the cerebellum, strongest expression in Purkinje cells and in the deep cerebellar nuclei. In retina, high expression in the ganglionic cell layer, inner nuclear layer and inthe ou
數據庫鏈接：

KEGG: mmu:80890

STRING: 10090.ENSMUSP00000069922

UniGene: Mm.44876