1. The activation of TRPM4 during ischemia-reperfusion injury involves the increase in both, intracellular calcium and H2O2, which may act together to produce a sustained activation of the channel. PMID: 28876976
2. Both TRPM4 and TRPM5 are required for normal responses to bitter, sweet, and umami stimuli. PMID: 29311301
3. The findings of this study demonstrated a novel molecular mechanism involving the SUR1-TRPM4-AQP4 complex to account for bulk water influx during astrocyte swelling. PMID: 28906027
4. Calcium studies demonstrated that TRPM4 channel negatively regulates calcium entry providing support for activation of the Cn-NFAT pathway in Trpm4 (-/-) mice. Authors provide evidence for the functional expression of TRPM4 channel in response to endurance training. PMID: 28224334
5. Study demonstrates that TRPM4 functions as a limiting factor for antigen evoked calcium rise in connective tissue type mast cells and concurrent translocation of TRPM4 into the plasma membrane is part of this mechanism. PMID: 27624684
6. Atrial TRPM4 channel is activated by a physiological range of Ca2+ concentrations and its excessive activity can cause arrhythmic changes. PMID: 28898995
7. electron cryo-microscopy structures of the mouse TRPM4 channel with and without ATP PMID: 29211714
8. Disrupting the Trpm4 gene in mice specifically eliminates NMDAR-dependent LTP. PMID: 26631168
9. observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation PMID: 26043922
10. The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores PMID: 26571400
11. The function of TRPM4 in renal primary cilia is not yet known, but it is likely to influence the apical Ca(2) dynamics of the cell PMID: 26290373
12. Deletion of the Trpm4 gene in mice improved survival and significantly enhanced beta-adrenergic cardiac reserve after inducing ischaemic heart failure. PMID: 25600961
13. TRPM4 has pleiotropic roles in the heart, including the regulation of conduction and cellular electrical activity which impact heart development. PMID: 25531103
14. The present study demonstrates that robust TRPM4-IR is localized specifically in the soma of Inner Auditory Hair Cells in the organ of Corti. PMID: 24840118
15. These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding. PMID: 25047048
16. Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice. PMID: 24972051
17. Results show that functional TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the ventricular heart muscle. PMID: 24226423
18. N-Glycosylation is not required for surface expression, but complex N-glycosylation stabilizes Trpm4b surface expression. PMID: 24214984
19. The results showed that TRPM4 is implicated in the waveform of the atrial action potential PMID: 23416167
20. The results of this study suggested that TRPC4, TRPM4, TRPM8 and TRPV1, showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP channel gene expression. PMID: 23410158
21. Experiments with FRET and co-immunoprecipitation showed de novo appearance of Sur1-Trpm4 heteromers after spinal cord injury in rats. PMID: 23255597
22. The TRPM4 channel contributes to survival in septic peritonitis; monocytes and macrophages (but not neutrophils) confer a survival advantage during sepsis through their expression of Trpm4. PMID: 22933633
23. SUR1 controls K(ATP) channel activity but not TRPM4 channels. PMID: 22291026
24. cell membrane depolarization by TRPM4 may play an important role in controlling glucagon secretion from alpha-cells and perhaps glucose homeostasis PMID: 21238535
25. discussion of data from various lines of investigation on the role of TRPM4 and TRPM5 in glucose-stimulated insulin secretion in pancreatic islets PMID: 21099334
26. We therefore conclude that TRPM4 proteins limit catecholamine release from chromaffin cells and that this contributes to increased sympathetic tone and hypertension. PMID: 20679729
27. Inhibition of Trpm4 expression increases divalent calcium ion influx and oscillatory calcium signaling levels in T helper (Th)2 cells and decreases influx and oscillations in Th1 cells. PMID: 20656926
28. PKCdelta activity causes smooth muscle depolarization and vasoconstriction by increasing the number of TRPM4 channels in the sarcolemma. PMID: 20610768
29. Voltage dependence is not due to block by divalent cations or to voltage-dependent binding of intracellular Ca2+ to an activator site, indicating that TRPM4 is a transient receptor potential channel with an intrinsic voltage-sensing mechanism. PMID: 12799367
30. Molecular cloning and characterization of TRPM4. PMID: 12893253
31. TRPM5 activated at lower Ca2+ concentration than TRPM4 when [Ca2+]i was raised. Different Ca2+ concentrations gave a difference in Ca2+ sensitivity between TRPM4 and TRPM5, with EC50 values of 20.2+/-4.0 microM & 0.70+/-0.1 microM, respectively. PMID: 15670874
32. hydrolysis of PI(4,5)P(2) underlies desensitization of TRPM4, and PI(4,5)P(2) is a general regulator for the gating of TRPM ion channels PMID: 16186107
33. TRPM4-regulated Ca(2+) homeostasis is crucial for DC mobility but not maturation PMID: 18758465
34. TRPM4 is critically involved in migration of bone marrow-derived mast cells by regulation of Ca(2+)-dependent actin cytoskeleton rearrangements. PMID: 19046767
35. Depolarizing currents generated by TRPM4 are an important component in the control of intracellular Ca(2+) signals necessary for insulin secretion and perhaps glucagon from alpha-cells. PMID: 19063936
36. in vivo gene suppression in rats treated with Trpm4 antisense or in Trpm4(-/-) mice preserved capillary structural integrity, eliminated secondary hemorrhage, yielded a 3x to 5x reduction in lesion volume and produced improvement in neurological function PMID: 19169264

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KEGG: mmu:68667

STRING: 10090.ENSMUSP00000040367

UniGene: Mm.439890