Recombinant Mouse Transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1)

中文名稱：

小鼠Tgfb1i1重組蛋白
貨號：

CSB-YP726787MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tgfb1i1重組蛋白
貨號：

CSB-EP726787MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tgfb1i1重組蛋白
貨號：

CSB-EP726787MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tgfb1i1重組蛋白
貨號：

CSB-BP726787MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tgfb1i1重組蛋白
貨號：

CSB-MP726787MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tgfb1i1
Uniprot No.：

Q62219
別名：

Tgfb1i1; Ara55; Transforming growth factor beta-1-induced transcript 1 protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein; Hic-5; TGF beta-stimulated clone 5; TSC-5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-461
氨基酸序列

MEDLDALLSD LETTTSHMSR LGAPKERPPE TLTPPPPYGH QPQTGSGESS GTTGDKDHLY STVCKPRSPK PVAPVAPPFS SSSGVLGNGL CELDRLLQEL NATQFNITDE IMSQFPSSKM AEGEEKEDQS EDKSSPTVPP SPFPAPSKPS ATSATQELDR LMASLSDFRV QNHLPASGPP QPPAASPTRE GCPSPPGQTS KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE HFLCSGCSTT LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT ALGTHWHPEH FCCVSCGEPF GEEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA LSALWHPDCF VCRECLAPFS GGSFFEHEGR PLCENHFHAQ RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERASKP YCQPCFLKLF G
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
基因功能參考文獻：
1. Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation. PMID: 28139974
2. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior PMID: 27893716
3. paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation. PMID: 27269065
4. Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta/Smad2 signaling by upregulation of Smad7 PMID: 26334580
5. Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. PMID: 25835392
6. Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis. PMID: 25587044
7. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. PMID: 24591583
8. Hic-5 is expressed in B16-F1 murine melanoma cells. PMID: 22883018
9. identified Hic-5 as a novel and specific regulatory factor for thrombin-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice. PMID: 22812543
10. the HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss PMID: 23007394
11. These data identify discrete roles for paxillin and Hic-5 in Rac1 and RhoA-dependent cell adhesion formation and maturation; processes essential for productive cell migration. PMID: 22629471
12. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
13. DNA-binding domain acetylation in the TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation PMID: 21515881
14. Findings indicate that Hic-5 may serve as a key regulator in mechanosensitive vascular remodeling. PMID: 20933520
15. Hic-5/ARA55 expression in response to castration-enabled epithelial regression through the repression of c-myc gene at the chromatin level. PMID: 20818421
16. These data suggest that the reduced expression of Hic-5 and concomitant reduced CTGF promoter activity may contribute to the anti-angiogenic effects of histone deacetylase inhibitors. PMID: 20333347
17. role in regulation of cellular phenotypes -review PMID: 12073614
18. Results suggest that paxillin and Hic-5 associate with GIT1 with different binding modes. PMID: 12153727
19. Results show that Hic-5 accumulates in the nucleus in response to oxidants such as hydrogen peroxide. PMID: 12631731
20. Important component in determining an epithelial differentiation program induced by PPARgamma. PMID: 15687259
21. hic-5 is a mediator of tensional force, translocating directly from focal adhesions to actin stress fibers upon mechanical stress and regulating the contractile capability of cells in the stress fibers PMID: 15713747
22. Repressive interference of LEF/TCF family members with HIC-5-mediated activation of glucocorticoid-driven transcription. PMID: 16291758
23. Altogether these results suggested that CS regulates focal contact activity in osteoblasts by modulating PYK2-containing complexes in particular by shuttling out of the focal contact the adaptor Hic-5 and favoring the anchorage of FAK within contacts. PMID: 16546139
24. Hic-5 as a key regulator of epithelial-mesenchymal transformation PMID: 17299801
25. demonstrate differential roles for individual Hic-5 isoforms during myogenesis and support the hypothesis that Hic-5 mediates these effects via integrin signaling. PMID: 17935713
26. These results suggest that Hic-5 modulates cellular responses to pathological stimuli in the vessel wall. PMID: 18812162
27. Data demonstrate that anchorage dependence is determined by anchorage-dependent nuclear retention of cyclin D1, which is regulated by the focal adhesion protein, Hic-5, whose CRM1-dependent nuclear export counteracts that of cyclin D1. PMID: 18946086
28. These findings demonstrate a novel role for hic-5 in the regulation of actin cytoskeleton and fetal gene expression. PMID: 19540241
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亞細胞定位：

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
蛋白家族：

Paxillin family
組織特異性：

Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth musc
數據庫鏈接：

KEGG: mmu:21804

STRING: 10090.ENSMUSP00000068529

UniGene: Mm.3248