Recombinant Mouse Transcription factor Sp6 (Sp6)

中文名稱：

小鼠Sp6重組蛋白
貨號：

CSB-YP863676MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Sp6重組蛋白
貨號：

CSB-EP863676MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Sp6重組蛋白
貨號：

CSB-EP863676MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sp6重組蛋白
貨號：

CSB-BP863676MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sp6重組蛋白
貨號：

CSB-MP863676MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sp6
Uniprot No.：

Q9ESX2
別名：

Sp6; Epfn; Klf14; Transcription factor Sp6; Epiprofin; Krueppel-like factor 14
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-376
氨基酸序列

MLTAVCGSLG SQHTDAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG ELQSLPLGPE VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM SHHYESWFRP THPGTEDGSW WDLHPGTSWM DLPHTQGALT SPGHPGALQP ALGGYVGDHQ LCAPPPHPHP HHLLPAAGGQ HLLGPPDGAK ALEAAAQESQ GLDSSLDAAS RPKGSRRSVP RSSGQTVCRC PNCLEAERLG APCGPDGGKK KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAAAAQGE GKAGGVVEPP GGKGKREAEG SSASSN
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Promotes cell proliferation.
基因功能參考文獻(xiàn)：
1. Whole body loss of KLF14 function in male mice does not result in metabolic abnormalities as assessed under chow and HFD conditions. PMID: 28962896
2. Results demonstrate that KLF14 expression is induced in the livers of normal C57BL/6J mice upon fasting and significantly up-regulated in the livers of db/db mice, suggesting a physiological link between KLF14 and gluconeogenesis. PMID: 29123026
3. Epfn preserves the balance between cell proliferation and cytodifferentiation in dental epithelial and mesenchymal cells during normal tooth development and morphogenesis. PMID: 27787957
4. epiprofin (Epfn, also known as Sp6) plays crucial distinct roles in these transition stages as a cell cycle regulator and a transcription factor. PMID: 25344255
5. Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm PMID: 25166858
6. Epfn enhances canonical Wnt/beta-catenin signaling in the developing dental pulp mesenchyme. PMID: 22868911
7. EPFN very likely functions as a modulator of WNT signaling in the limb ectoderm. PMID: 19913006
8. Epiprofin is a highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth PMID: 14551215
9. the Sp6 transcript possesses a first exon distinct from the epiprofin one PMID: 17624655
10. Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation PMID: 18156176
11. Data suggest that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis. PMID: 18297738
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Sp1 C2H2-type zinc-finger protein family
組織特異性：

Ubiquitous. Preferentially expressed by proliferating epithelial cells of teeth, hair follicles and limbs.
數(shù)據(jù)庫鏈接：

KEGG: mmu:83395

STRING: 10090.ENSMUSP00000039307

UniGene: Mm.156282