Recombinant Mouse Transcription factor SOX-7 (Sox7)

中文名稱：

小鼠Sox7重組蛋白
貨號：

CSB-YP022435MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Sox7重組蛋白
貨號：

CSB-EP022435MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Sox7重組蛋白
貨號：

CSB-EP022435MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sox7重組蛋白
貨號：

CSB-BP022435MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sox7重組蛋白
貨號：

CSB-MP022435MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sox7
Uniprot No.：

P40646
別名：

Sox7; Sox-7; Transcription factor SOX-7; mSOX7
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-380
氨基酸序列

MASLLGAYPW TEGLECPALE AELSDGLSPP AVPRPSGDKS SESRIRRPMN AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER LRLQHMQDYP NYKYRPRRKK QGKRLCKRVD PGFLLSSLSR DQNTLPEKNG IGRGEKEDRG EYSPGATLPG LHSCYREGAA AAPGSVDTYP YGLPTPPEMS PLDALEPEQT FFSSSCQEEH GHPHHLPHLP GPPYSPEFTP SPLHCSHPLG SLALGQSPGV SMMSSVSGCP PSPAYYSHAT YHPLHPNLQA HLGQLSPPPE HPGFDTLDQL SQVELLGDMD RNEFDQYLNT PGHPDSAAGV GTLTGHVPLS QGTPTGPTET SLISVLADAT ATYYNSYSVS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscle markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.
基因功能參考文獻：
1. SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival. PMID: 28943254
2. By E10.5, both Sox7 complete knockout and FLK1-specific deletion of Sox7 lead to widespread vascular defects. In contrast, while SOX7 is expressed in the earliest specified blood progenitors, the VAV-specific deletion of Sox7 does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development. PMID: 28577909
3. Data provide evidence that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis with alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis. PMID: 27411892
4. SOX7 inhibits the expression of RUNX1 target genes in hemogenic endothelium, while having no effect on RUNX1 expression itself. SOX7 directly interacts with RUNX1 and inhibits its transcriptional activity. PMID: 27802172
5. Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation. PMID: 28334937
6. These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system. PMID: 26475439
7. ETV2 directly regulates Sox7, and ETV2 governs endothelial development by regulating transcriptional networks which include Sox7. PMID: 24762086
8. Notch and SoxF factors combinatorially regulate Dll4 expression in arteries downstream of VEGF. PMID: 23818617
9. Haploinsufficiency of Sox7 or Gata4 is sufficient to produce anterior congenital diaphragmatic hernia in mice. PMID: 22723016
10. SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. PMID: 22492353
11. Sox7-sustained expression in the earliest committed hematopoietic precursors promotes the maintenance of their multipotent and self-renewing status. PMID: 19801444
12. SOX7 and GATA-4 are competitive activators of Fgf-3 transcription PMID: 15082719
13. is required for the induction of Gata-4 and Gata-6, and the interplay among these transcription factors plays a crucial role in parietal endoderm differentiation PMID: 15542856
14. differential Sox7 gene expression presents a novel biomarker profile, and possible regulatory switch, to distinguish cardiovascular pedigrees within Flk-1(+) multi-lineage progenitors PMID: 19272523
15. both Sox7 and Sox15 are able to induce the early stages of myogenesis. PMID: 19489079
16. comparison with human gene, chromosome mapping, gene expression, transactivation domain PMID: 11691915
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亞細胞定位：

Nucleus. Cytoplasm.
組織特異性：

Predominantly expressed in ovary, lung and heart. In the ovary, restricted to oocytes (at protein level). Present both in mesenchymal and epithelial cells in some adult tissues, including ear.
數據庫鏈接：

KEGG: mmu:20680

STRING: 10090.ENSMUSP00000078597

UniGene: Mm.42162