Recombinant Mouse Transcription factor HES-7 (Hes7)

中文名稱：

小鼠Hes7重組蛋白
貨號：

CSB-YP806395MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hes7重組蛋白
貨號：

CSB-EP806395MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hes7重組蛋白
貨號：

CSB-EP806395MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hes7重組蛋白
貨號：

CSB-BP806395MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hes7重組蛋白
貨號：

CSB-MP806395MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hes7
Uniprot No.：

Q8BKT2
別名：

Hes7; Transcription factor HES-7; mHes7; Hairy and enhancer of split 7; bHLH factor Hes7
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-225
氨基酸序列

MVTRERAENR DGPKMLKPLV EKRRRDRINR SLEELRLLLL ERTRDQNLRN PKLEKAEILE FAVGYLRERS RVEPPGVPRS PGQDAEALAS CYLSGFRECL LRLAAFAHDA SPAARSQLFS ALHGYRRPKP PRPEAVDPGL PAPRPPLDPA SPILGPALHQ RPPVHQGPPS PRLAWSPSHC SSRAGDSGAP APLTGLLPPP PPPYRQDGAP KAPSLPPPAF WRPWP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
基因功能參考文獻：
1. Hes7 oscillation is synchronized between neighboring cells, and the posterior-anterior axis is self-organized as the central-peripheral axis PMID: 29437832
2. Lengthening the third Hes7 intron by 10 or 20 kb disrupts accurate RNA splicing and inactivates the gene. PMID: 22326607
3. Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2, suggesting gene-environment interaction through this signaling. PMID: 23465881
4. Hes7 is a key regulator of the pace of the segmentation clock. PMID: 23219549
5. Tbx6 and the Wnt pathway cooperatively regulate proper Hes7 expression. PMID: 23326414
6. introns lead to an approximately 19-min delay in the Hes7 gene expression, and mathematical modeling suggested that without such a delay, Hes7 oscillations would be abolished PMID: 21300886
7. there are differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis PMID: 19956724
8. periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock PMID: 12783854
9. instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock PMID: 15170214
10. Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis by forming negative feedback loop PMID: 16342160
11. Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling. PMID: 17681139
12. repressor functionality and the half-life of the protein is crucial for oscillatory expression of Hes7 and regular somite formation PMID: 17983837
13. These results indicate that common amino acid residues are involved in both the transcriptional repressor activity and the instability of Hes7 protein, suggesting of a critical link between the transcription and degradation control. PMID: 18477475
14. Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter. PMID: 19440349
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: mmu:84653

STRING: 10090.ENSMUSP00000024543

UniGene: Mm.98505