Recombinant Mouse Transcription cofactor HES-6 (Hes6)

中文名稱：

小鼠Hes6重組蛋白
貨號：

CSB-YP872824MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hes6重組蛋白
貨號：

CSB-EP872824MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hes6重組蛋白
貨號：

CSB-EP872824MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hes6重組蛋白
貨號：

CSB-BP872824MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hes6重組蛋白
貨號：

CSB-MP872824MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hes6
Uniprot No.：

Q9JHE6
別名：

Hes6; Transcription cofactor HES-6; Hairy and enhancer of split 6
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-224
氨基酸序列

MAPSQAPSRD RAGQEDEDRW EARGDRKARK PLVEKKRRAR INESLQELRL LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA EASERFAAGY IQCMHEVHTF VSTCQAIDAT VSAELLNHLL ESMPLREGSS FQDLLGDSLA GLPGGSGRSS WPPGGSPESP LSSPPGPGDD LCSDLEEIPE AELNRVPAEG PDLVSTSLGS LTAARRAQSV WRPW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
基因功能參考文獻：
1. Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons. PMID: 26105991
2. Hes6 physically and functionally interacts with RelA-containing NF-kappaB complexes in cortical progenitor cells to control cortical neurogenesis. PMID: 23689134
3. Hes6 regulates myogenic differentiation. PMID: 11959828
4. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
5. Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation. PMID: 17065448
6. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
7. Data reveal a role for Ascl1 in the regulation of Hes6, a proneurogenic factor that inhibits Notch signaling to promote neural rather than glial differentiation PMID: 19191219
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in both undifferentiated and differentiated cells. High levels of expression are observed in several embryonic tissues including the nervous system, muscle and thymus. In the nervous system, initially expressed in the closing neural tube, then i
數據庫鏈接：

KEGG: mmu:55927

STRING: 10090.ENSMUSP00000084062

UniGene: Mm.280029