Recombinant Mouse Synaptotagmin-like protein 4 (Sytl4)

中文名稱：

小鼠Sytl4重組蛋白
貨號：

CSB-YP870808MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Sytl4重組蛋白
貨號：

CSB-EP870808MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Sytl4重組蛋白
貨號：

CSB-EP870808MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sytl4重組蛋白
貨號：

CSB-BP870808MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Sytl4重組蛋白
貨號：

CSB-MP870808MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sytl4
Uniprot No.：

Q9R0Q1
別名：

Sytl4; Slp4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-673
氨基酸序列

MSEILDLSFL SEMERDLILG VLQRDEELRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD RTCARCQEGL GRLIPKSSTC VGCNHLVCRE CRVLESNGSW RCKVCSKEIE LKKATGDWFY DQKVNRFDYR TGSEIIRMSL RQKPAVNKRE TAGQSLLQQT QMGDIWPGRR IIQEQQQREQ SVLFEVPKTR SGKSALEAES ESLDSYTADS DSTSRRDSLD KSGLFPEWKK MSAPKSQVEK EIPPGNQNAV CGDEGDMVFK KNTKKVLRPS EYTKSVIDLR PEDVAQESGI LGDRSKSVPG LSVDMEEEEE EEEDIDHLVK LHRQKLARGS MQSGSSMSTL GSIMSIYSEA GDFGNISVTG KIAFSLKFEQ KTQTLVIHVK ECHQLAYADE AKKRSNPYVK TYLLPDKSRQ GKRKTSIKRD TINPLYDETF RYEISESLLA QRTLQFSVWH HGRFGRNTFL GEAEVHMDSW KLDKKLDHCL PLHGKISTES SPGLPAHKGE LVVSLKYIPA SKLPVGGDRK KSKGGEGGEL QVWIKEAKNL TAAKSGGTSD SFVKGYLLPM RNKASKRKTP VMKKTLSPHY NHTFVYNGVR LEDLQHMCLE LTVWDREPLA SNDFLGGVRL GVGTGISNGE VVDWMDSTGE EVSLWQKMRQ YPGSWAEGTL QLRSSMVKQK LGV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.
基因功能參考文獻：
1. Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively. PMID: 23223571
2. granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a PMID: 15028737
3. It is shown that the granuphilin promoter is a target of SREBP-1c, a transcription factor that controls fatty acid synthesis, and MafA, a beta cell differentiation factor PMID: 16890542
4. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp4 specifically and directly binds the GTP-bound form of Rab3A, Rab8, and Rab27A. PMID: 11773082
亞細胞定位：

Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
組織特異性：

Detected in the pancreatic islet, in particular in insulin-positive beta cells, and in pituitary.
數據庫鏈接：

KEGG: mmu:27359

STRING: 10090.ENSMUSP00000033608

UniGene: Mm.38674