Recombinant Mouse Sperm-associated antigen 6 (Spag6)

中文名稱：

小鼠Spag6重組蛋白
貨號：

CSB-YP862410MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Spag6重組蛋白
貨號：

CSB-EP862410MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Spag6重組蛋白
貨號：

CSB-EP862410MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Spag6重組蛋白
貨號：

CSB-BP862410MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Spag6重組蛋白
貨號：

CSB-MP862410MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Spag6
Uniprot No.：

Q9JLI7
別名：

Spag6; Pf16; Sperm-associated antigen 6; Axoneme central apparatus protein; Protein PF16 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-507
氨基酸序列

MSQRQVLQVF EQYQKARTQF VQMVAELATR PQNIETLQNA GVMSLLRPLL LDVVPTIQQT AALALGRLAN YNDDLAEAVV KGDILPQLVY SLAEQNRFYK KAAAFVLRAV GKHSPQLAQA IVDCGALDTL VICLEDFDPG VKEAAAWALG YIARHNTELS QAVVDAGAIP LLVLCIQEPE IALKRIAASA LSDISKHSPE LAQTVVDAGA IAHLAQMILN PDAKLKRQVL SALSQIAKHS VDLAEMVVEA EIFPVVLTCL KDKDEYVKKN ACTLIREIAK HTPELSQLIV NAGGVAAVID CIGSCKGNIR LPGIMMLGYV AAHSENLAMA VIISKGVPQL SICLSEEPED HIKAAAAWAL GQLGRHTPEH ARAVAVTNTL PVLLSLYMSP ESSEDLQLKS KKAIKNILQK CTYLPALEPF LYDAPPNILK HVVGQFSKVL PHDSKARRLF VTSGGLKKVQ EIKAEPGSLL QEYINSINNC YPEEIVRYYS PGYSDTLLQR VDSYQPL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
基因功能參考文獻(xiàn)：
1. SPAG6 binds to prestin in vivo and contributes to fix prestin biomolecules in lateral plasma membrane of outer hair cells. PMID: 25748314
2. Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia. PMID: 12167721
3. Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein. PMID: 12391165
4. Accelerated mortality from hydrocephalus and pneumonia in mice with combined deficiency of Spag6 and Spag16L reveals a functional interrelationship between the two central apparatus proteins. PMID: 17323374
5. Spag6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia. PMID: 17971504
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相關(guān)疾病：

Defects in Spag6 are a cause of hydrocephalus and of male infertility.
亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.
組織特異性：

Highly expressed in testis. Not detected in prostate, ovary, spleen, thymus, small intestine, colon and peripheral blood leukocytes.
數(shù)據(jù)庫鏈接：

KEGG: mmu:50525

STRING: 10090.ENSMUSP00000023468

UniGene: Mm.31701