Recombinant Mouse Solute carrier family 23 member 2 (Slc23a2), partial

中文名稱：

小鼠Slc23a2重組蛋白
貨號：

CSB-YP872107MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Slc23a2重組蛋白
貨號：

CSB-EP872107MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Slc23a2重組蛋白
貨號：

CSB-EP872107MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Slc23a2重組蛋白
貨號：

CSB-BP872107MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Slc23a2重組蛋白
貨號：

CSB-MP872107MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc23a2
Uniprot No.：

Q9EPR4
別名：

Slc23a2; Kiaa0238; Svct2; Yspl2; Solute carrier family 23 member 2; Na(+)/L-ascorbic acid transporter 2; Sodium-dependent vitamin C transporter 2; SVCT-2; mSVCT2; Yolk sac permease-like molecule 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
基因功能參考文獻：
1. SVCT2 was also detected in progenitor cells located in the inner and outer subventricular zone PMID: 27596508
2. This study found impaired myelination and reduced collagen expression in Sodium-dependent Vitamin C Transporter 2 heterozygous mice (SVCT2(+/-) ) during peripheral nerve development and after peripheral nerve injury. PMID: 28456003
3. Data show that phosphorylation of caveolin-1 on Tyr(14) in microglia induced the internalization of sodium-vitamin C cotransporter 2 (SVCT2). PMID: 28351945
4. Study shows that SVCT2 is regulated at the post-transcriptional level by miR-141 and miR-200a during osteogenic differentiation of bone marrow stromal cells. PMID: 25617715
5. Results indicate that both the SVCT2 transporter and oxidative stress play a vital role in BMSC attachment, migration and cytoskeletal re-arrangement. PMID: 24365600
6. The functional expression of SVCT2 was detected in HEK293 cells.The kinetic analysis suggested that an ascorbate-dependent mechanism accounts for targeted SVCT2 expression in the developing kidney during medullary epithelial cell differentiation. PMID: 22990596
7. Using in vitro studies, we suggest a molecular interaction between the SVCT2wt and SVCT2sh isoforms, which may regulate the affinity of vitamin C uptake PMID: 24947427
8. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against oxidative stress. PMID: 22558179
9. the expression and transport activity of SVCT2 in brain capillary endothelial cells after transient ischemia PMID: 21347255
10. Expression of various collagen types is reduced in sciatic nerves of SVCT2(+/-) heterozygous mice compared to wild-type. PMID: 22114285
11. The results suggest that expression of the SVCT2 is differentially regulated during embryonic development and in adulthood. PMID: 22001929
12. Selective macrophage ascorbate deficiency suppresses early atherosclerosis. PMID: 20974251
13. Evidence of increased apoptosis in SVCT2(-/-) mice and disruption of the basement membrane in fetal brain. PMID: 20541602
14. These results provide evidence for the first time that uptake of ascorbic acid in the peripheral nervous system is crucially dependent on the expression and activity of SVCT2. PMID: 19672970
15. an ascorbic acid transporter essential for vitamin c transport into the brain, and for perinatal survival PMID: 11984597
16. A deficiency of Ca(2+) or PO(4)(3-) inhibits SVCT2 expression in a time-dependent manner. PMID: 12788230
17. We examined the roles of L-ascorbic acid (AA) and its transporter, sodium-dependent vitamin C transporter (SVCT) 2, in the Zn-induced expression of osteoblastic differentiation markers. PMID: 14622981
18. SVCT2 is highly expressed in the apical membranes of mouse hypothalamic tanycytes. Vitamin C uptake mechanisms present in these cells may perform a neuroprotective role concentrating vitamin C in this brain area . PMID: 15625716
19. Our results revealed that maintenance of intracellular ascorbate as a result of SVCT2 activity is crucial for neuronal development, functional maturation, and antioxidant responses. PMID: 17304569
20. PGE2-induced SVCT2 plasma membrane translocation through EP4 receptor and phosphorylation of SVCT2 by PKA increases ascorbic acid uptake and osteoblast-like differentiation in MC3T3-E1 cells. PMID: 17585336
21. These results show that mature erythrocytes fail to concentrate ascorbate due to the loss of SVCT2 during maturation in the bone marrow. PMID: 17586466
22. Transcription of the SVCT2 gene could be positively or negatively modulated by the presence of oxidant (H(2)O(2)) or antioxidant (lipoate) compounds, respectively. PMID: 17643393
23. This study showed that sodium-dependent vitamin C transporter 2 mediated increases in ascorbic acid uptake by the adrenals followed by excessive production of plasma norepinephrine may play a pivotal role in the development of diabetic complications. PMID: 17689499
24. all three proximal tubule segments expressed the transporter but the S3 segment had the highest expression; Ascorbic acid transport in these cells was regulated by a single kinetic component that depended on the sodium concentration, pH and temperature PMID: 18614995
25. Culture of the macrophages with oxLDL enhanced ascorbate uptake. This was associated with increased expression of the ascorbate transporter (SVCT2), which was prevented by ascorbate and by inhibiting the NF-kappaB pathway PMID: 19254685
26. knock-out mice die at birth due to tissue ascorbate deficiency PMID: 19361554
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相關疾病：

Elevated expression levels in the adrenals of diabetic mice.
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Xanthine/uracil permease family, Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
組織特異性：

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.
數據庫鏈接：

KEGG: mmu:54338

STRING: 10090.ENSMUSP00000028815

UniGene: Mm.103581