Recombinant Mouse Solute carrier family 22 member 6 (Slc22a6), partial

中文名稱：

小鼠Slc22a6重組蛋白
貨號(hào)：

CSB-YP819737MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Slc22a6重組蛋白
貨號(hào)：

CSB-EP819737MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Slc22a6重組蛋白
貨號(hào)：

CSB-EP819737MO-B
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Slc22a6重組蛋白
貨號(hào)：

CSB-BP819737MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Slc22a6重組蛋白
貨號(hào)：

CSB-MP819737MO
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc22a6
Uniprot No.：

Q8VC69
別名：

Slc22a6; Nkt; Oat1; Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; Renal organic anion transporter 1; mROAT1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. Mediates the sodium-independent uptake of p-aminohippurate (PAH). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid and PKC activators.
基因功能參考文獻(xiàn)：
1. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). PMID: 30336599
2. It is the key assembly for uric acid secretion through kidney. PMID: 29595077
3. OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported. PMID: 28689374
4. An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network. PMID: 27440044
5. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3). PMID: 26788513
6. OAT1-deficient mice showed abnormal LTP and higher spine numbers but with a much lesser maturity extent. PMID: 25725783
7. At the protein level, mOat3 and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation. PMID: 23389457
8. Oat1 potentially plays a major role in the rate limiting step in the uptake and excretion of putative toxic metabolites PMID: 21476605
9. acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1. PMID: 21652719
10. functional differences in the relative importance of OAT1 and OAT3 in antiviral handling in developing and mature tissue PMID: 20921221
11. the ontogenic pattern of expression of OAT1 and OAT3 in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus PMID: 19924639
12. Although all cysteine mutants of mOAT1 were sensitive to the inhibition by PCMBS, C49A was less sensitive than the wild-type mOAT1, suggesting that the modification of Cys49 may play a role in the inhibition of mOAT1 by PCMBS. PMID: 14979872
13. analysis of physiological substrates of OAT1 PMID: 16354673
14. the substrate binding preferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the more broadly expressed transporter, Oat1 PMID: 17553798
15. The constitutive expression of OAT1 in the kidney is regulated by both HNF1alpha and HNF1beta. PMID: 18029548
16. despite sharing close overall sequence homology, Oat1, Oat3, and Oat6 have signficantly different binding pockets PMID: 18174163
17. data demonstrate that PKCzeta activation up-regulates OAT1 and OAT3 function, and that protein-protein interactions play a central role controlling these two important renal drug transporters PMID: 19028678
18. Oat1, Oat3, and Oat6 function largely in organic anion transport but also bind and transport organic cations. PMID: 19737926
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Note=Localized to the plasma membrane.
蛋白家族：

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
組織特異性：

Expressed in kidney; in the basolateral membrane and at much lower levels in brain.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:18399

STRING: 10090.ENSMUSP00000010250

UniGene: Mm.30090