Recombinant Mouse Smoothelin-like protein 1 (Smtnl1)

中文名稱：

小鼠Smtnl1重組蛋白
貨號：

CSB-YP859977MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Smtnl1重組蛋白
貨號：

CSB-EP859977MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Smtnl1重組蛋白
貨號：

CSB-EP859977MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Smtnl1重組蛋白
貨號：

CSB-BP859977MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Smtnl1重組蛋白
貨號：

CSB-MP859977MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Smtnl1
Uniprot No.：

Q99LM3
別名：

Smtnl1; Smoothelin-like protein 1; Calponin homology-associated smooth muscle protein; CHASM
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-459
氨基酸序列

MEQTEGNSSE DGTTVSPTAG NLETPGSQGI AEEVAEGTVG TSDKEGPSDW AEHLCKAASK SGESGGSPGE ASILDELKTD LQGEARGKDE AQGDLAEEKV GKEDTTAASQ EDTGKKEETK PEPNEVREKE EAMLASEKQK VDEKETNLES KEKSDVNDKA KPEPKEDAGA EVTVNEAETE SQEEADVKDQ AKPELPEVDG KETGSDTKEL VEPESPTEEQ EQGKENESEE RAAVIPSSPE EWPESPTDEG PSLSPDGLAP ESTGETSPSA SESSPSEVPG SPTEPQPSEK KKDRAPERRV SAPSRPRGPR AQNRKAIMDK FGGAASGPTA LFRNTKAAGA AIGGVKNMLL EWCRAMTRNY EHVDIQNFSS SWSSGMAFCA LIHKFFPEAF DYAELDPAKR RHNFTLAFST AEKLADCAQL LEVDDMVRLA VPDSKCVYTY IQELYRSLVQ KGLVKTKKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity.
基因功能參考文獻：
1. Pregnancy promotes switching of skeletal muscle to a glycolytic phenotype through the smoothelin-like protein 1 transcriptional cofactor. PMID: 26048986
2. Two domains of SMTNL1 bind apo- and calcium-calmodulin independently. PMID: 24905744
3. appears that the type-2 CH domain of CHASM is required for tropomyosin binding and presents a novel function for this protein domain PMID: 22424482
4. SMTNL1 is a bifunctional co-regulator of PR-B signaling and provides a molecular mechanism whereby PR-B is targeted to alter gene expression patterns within uterine smooth muscle cells to coordinately promote alterations in USM function during pregnancy PMID: 21771785
5. The Smtnl1 proximal promoter enhances expression up to 8-fold in smooth muscle cells and a second activating region lays 500 bp further upstream. PMID: 21352594
6. Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and MYPT1. PMID: 20634291
7. An interaction between CHASM and tropomyosin, is demonstrated. PMID: 20627103
8. CHASM is a novel member of the smoothelin protein family that elicits Ca2+ desensitization in smooth muscle PMID: 15327999
9. SMTNL1 has roles in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity PMID: 18310078
10. revealed a close interaction of SMTNL1-homology with the two Ca(2+) binding loop regions of the C-terminal domain of apo-calmodulin PMID: 18477568
11. A knock out mouse for this gene shows an exercise adapted phenotype. The encoded protein has a unique expression profile in striated muscle both in mice and human. PMID: 18310078
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亞細胞定位：

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus.
蛋白家族：

Smoothelin family
組織特異性：

Widely expressed, with highest expression in skeletal muscles (at protein level). Within striated muscles, significantly more expressed in soleus muscle compared with plantaris muscle or white vastus (at protein level). 30-40% lower expression in females
數據庫鏈接：

KEGG: mmu:68678

STRING: 10090.ENSMUSP00000028471

UniGene: Mm.33452