Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2 (Ash2l)

中文名稱：

Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2(Ash2l)
貨號：

CSB-YP849667MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2(Ash2l)
貨號：

CSB-EP849667MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2(Ash2l)
貨號：

CSB-EP849667MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2(Ash2l)
貨號：

CSB-BP849667MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Set1/Ash2 histone methyltransferase complex subunit ASH2(Ash2l)
貨號：

CSB-MP849667MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ash2l
Uniprot No.：

Q91X20
別名：

Ash2lSet1/Ash2 histone methyltransferase complex subunit ASH2; ASH2-like protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-623
氨基酸序列

MAAAGAGPGP GVSAGPGPGA AASATTAEDR ETEPVAAGAG EGPSAAPGAE PSSGEAESGD ANLVDVSGLE TESSNGKDTL EGTGDTSEVM DTQAGSVDEE NGRQLGEVEL QCGICTKWFT ADTFGIDTSS CLPFMTNYSF HCNVCHHSGN TYFLRKQANL KEMCLSALAN LTWQSRTQDE HPKTMFSKDK DIIPFIDKYW ECMTTRQRPG KMTWPNNIVK TMSKERDVFL VKEHPDPGSK DPEEDYPKFG LLDQDLSNIG PAYDNQKQSS AVSASGNLNG GIAAGSSGKG RGAKRKQQDG GTTGTTKKAR SDPLFSAQRL PPHGYPLEHP FNKDGYRYIL AEPDPHAPDP EKLELDCWAG KPIPGDLYRA CLYERVLLAL HDRAPQLKIS DDRLTVVGEK GYSMVRASHG VRKGAWYFEI TVDEMPPDTA ARLGWSQPLG NLQAPLGYDK FSYSWRSKKG TKFHQSIGKH YSSGYGQGDV LGFYINLPED TETAKSLPDT YKDKALIKFK SYLYFEEKDF VDKAEKSLKQ TPHSEIIFYK NGVNQGVAYR DIFEGVYFPA ISLYKSCTVS INFGPSFKYP PKDLTYHPMS DMGWGAVVEH TLADVLYHVE TEVDGRRSPP WEP
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
基因功能參考文獻(xiàn)：
1. Ash2l-1 and Ash2l-2 are involved in the maintenance of mESCs pluripotency and the regulation of genomic H3K4me3. PMID: 29576547
2. We discuss the implications of these results to understand the role of ASH2L and Xist repeat E for histone modifications and escape gene regulation during random X-chromosome inactivation. PMID: 28686623
3. ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers PMID: 25258321
4. Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells PMID: 23239880
5. Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 is a novel direct target of these complexes. PMID: 20046871
6. Ap2delta associates with ASH2L and MLL2 (ALR), forming a complex that methylates lysine 4 of histone H3. PMID: 18495928
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亞細(xì)胞定位：

Nucleus.
組織特異性：

Ubiquitously expressed, with abundant expression in the heart, skeletal muscle and kidney. Low expression is seen in spleen, lung and testis.
數(shù)據(jù)庫鏈接：

KEGG: mmu:23808

STRING: 10090.ENSMUSP00000070957

UniGene: Mm.27706