Recombinant Mouse Serum amyloid P-component (Apcs)

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

CSB-YP001898MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

CSB-EP001898MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

CSB-EP001898MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

CSB-BP001898MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

CSB-MP001898MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Apcs
Uniprot No.：

P12246
別名：

Apcs; Ptx2; Sap; Serum amyloid P-component; SAP
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

21-224
氨基酸序列

QTDLKRKVFV FPRESETDHV KLIPHLEKPL QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP NILNWQALNY EINGYVVIRP RVWD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines PMID: 26649902
2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene. PMID: 22274563
5. binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis PMID: 21753147
6. SAP has an effect on macrophages in fibrotic lung disease PMID: 20300636
7. sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis. PMID: 20472109
8. Serum amyloid P is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis. PMID: 20065116
9. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus. PMID: 11984001
10. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis PMID: 12015594
11. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB PMID: 16298151
12. SAP may modulate the inflammatory response to amyloid fibrils in atherosclerosis PMID: 17630380
13. These results show a novel and physiologically significant role for SAP for complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the importance of the classical complement pathway for innate immunity. PMID: 17845072
14. Cells sensing they are inflicted with mortal injury can turn on molecular programs insuring not only that they die by apoptosis but also that once they are dead their elimination is (facilitated by SAP) swift and efficient. PMID: 18046483
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相關疾病：

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
亞細胞定位：

Secreted.
蛋白家族：

Pentraxin family
數據庫鏈接：

KEGG: mmu:20219

STRING: 10090.ENSMUSP00000027824

UniGene: Mm.330510