Recombinant Mouse Serine protease inhibitor A3G (Serpina3g)

中文名稱：

小鼠Serpina3g重組蛋白
貨號：

CSB-YP683291MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Serpina3g重組蛋白
貨號：

CSB-EP683291MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Serpina3g重組蛋白
貨號：

CSB-EP683291MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Serpina3g重組蛋白
貨號：

CSB-BP683291MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Serpina3g重組蛋白
貨號：

CSB-MP683291MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Serpina3g
Uniprot No.：

Q5I2A0
別名：

Serine protease inhibitor 2A; Serine protease inhibitor A3G; Serpin 2A; Serpin A3G; Serpina3g; SPA3G_MOUSE
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-440
氨基酸序列

MAGVSPAVFG CPDVTLGRNT AVREVQENVT SVDSLTLVSS NTDFAFSLYR KLVLKNPDEN VVFSPFSICT ALALLSLGAK SNTLKEILEG LKFNLTETPE PDIHQGFRYL LDLLSQPGNQ VQISTGSALF IEKHLQILAE FKEKARALYQ AEAFTADFQQ PLKATKLIND YVSNHTQGKI KELISGLKES TLMVLVNYIY FKGKWKNPFD PNDTFKSEFY LDEKRSVIVS MMKTGYLTTP YFRDEELSCT VVELKYTGNA SAMFILPDQG RMQQVEASLQ PETLRKWKNS LKPRMIHELR LPKFSISTDY SLEHILPELG IREVFSTQAD LSAITGTKDL RVSQVVHKAV LDVAETGTEA AAATGMAGVG CCAVFDFLEI FFNRPFLMII SDTKAHIALF MAKVTNPERS MNFPNGEGAS SQRLESKRLC FGDPLCLIGQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells.
基因功能參考文獻：
1. Authors define roles for an HP-regulated Serpina3g/Spi2A intracellular serpin during granulomyelocytic, B-cell, and hematopoietic stem cell (HSC) formation. PMID: 24964278
2. SerpinA3g plays a role in the TNF-alpha modulation of adipose tissue development and metabolism. PMID: 24973688
3. inhibition of lysosomal executioner proteases by Spi2A is a physiological mechanism by which cells are protected from caspase-independent programmed cell death PMID: 15225607
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Serpin family
組織特異性：

Expressed in bone marrow (particularly hematopoietic stem cells), heart, kidney, liver, lung, skeletal muscle, spleen, testis, thymus and T-cells.
數據庫鏈接：

KEGG: mmu:20715

STRING: 10090.ENSMUSP00000041250

UniGene: Mm.312628