Recombinant Mouse STE20-like serine/threonine-protein kinase (Slk), partial

中文名稱：

小鼠Slk重組蛋白
貨號：

CSB-YP021776MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Slk重組蛋白
貨號：

CSB-EP021776MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Slk重組蛋白
貨號：

CSB-EP021776MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Slk重組蛋白
貨號：

CSB-BP021776MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Slk重組蛋白
貨號：

CSB-MP021776MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slk
Uniprot No.：

O54988
別名：

Slk; Kiaa0204; Stk2; STE20-like serine/threonine-protein kinase; STE20-like kinase; mSLK; EC 2.7.11.1; Etk4; STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates apoptosis and actin stress fiber dissolution.
基因功能參考文獻：
1. Loss of SLK impairs myofiber stability and function. PMID: 28153048
2. Essential role for the SLK protein kinase in embryogenesis and placental tissue development. PMID: 24868594
3. SLK phosphorylates the adhesion adapter protein paxillin on serine 250. This is required for FAK-dependent focal adhesion dynamics. PMID: 23128389
4. Data suggest that podocyte Ste20-like kinase (SLK) overexpression in vivo results in injury and podocyte loss, consistent with the effects of SLK in cultured cells. PMID: 20889563
5. Data suggest that Ldb1/2 function to maintain SLK in an inactive state before its activation. PMID: 19675209
6. Associates with microtubules and has a role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading PMID: 12151406
7. SLK is expressed in the neurons and neuroepithelium of the developing embryo in the forebrain, midbrain and hindbrain. Following middle cerebral artery occlusion, SLK neurons are lost and SLK is localized to phagocytic macrophages/microglia. PMID: 12480135
8. identification and characterization of a novel enzyme expressed in erythroleukemia cells PMID: 12574163
9. SLK expression induced in Myf5- and Pax7-positive activated satellite cells during regeneration and expression of dominant negative Ste20-like kinase SLK in C2C12 cultures impairs myoblast fusion PMID: 15052621
10. Overexpression of active SLK resulted in ectopic spindle assembly and the induction of cell cycle re-entry of Xenopus oocytes, suggesting that SLK is required for progression through G2 upstream of H1 kinase activation PMID: 16236704
11. SLK represents a novel focal adhesion disassembly signal PMID: 18382658
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

KEGG: mmu:20874

STRING: 10090.ENSMUSP00000049977

UniGene: Mm.281011