Recombinant Mouse SH2 domain-containing protein 3C (Sh2d3c), partial

中文名稱：

小鼠Sh2d3c重組蛋白
貨號(hào)：

CSB-YP865616MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Sh2d3c重組蛋白
貨號(hào)：

CSB-EP865616MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Sh2d3c重組蛋白
貨號(hào)：

CSB-EP865616MO-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Sh2d3c重組蛋白
貨號(hào)：

CSB-BP865616MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Sh2d3c重組蛋白
貨號(hào)：

CSB-MP865616MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sh2d3c
Uniprot No.：

Q9QZS8
別名：

Sh2d3c; Chat; Shep1; SH2 domain-containing protein 3C; Cas/HEF1-associated signal transducer; SH2 domain-containing Eph receptor-binding protein 1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response. Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1. Promotes cell migration and invasion through the extracellular matrix. Required for marginal zone B-cell development and thymus-independent type 2 immune responses. Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL. Plays a role in CXCL13-induced chemotaxis of B-cells. Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development. Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons.; Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1. Required for tissue-specific adhesion of T lymphocytes to peripheral tissues. Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9. May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells.; May be involved in the BCAR1/CAS-mediated JNK activation pathway.
基因功能參考文獻(xiàn)：
1. Chat-H regulates atherosclerosis development by controlling monocyte adhesion and recruitment to the plaques. PMID: 27417580
2. Shep1 plays a critical role in the in vivo regulation of Src activity and Cas downstream signaling through Crk protein. PMID: 20603213
3. SHEP1 and CasL are constitutively associated in B cells. PMID: 20956287
4. Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain. PMID: 20881139
5. Sh2d3c is required for proper localization of cells, particularly marginal zone B cells in vivo; thymi of Sh2d3c-deficient mice show no maturational abnormalities. PMID: 20505138
6. glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth factor (EGF), implying that these activities of SHEP1 depend upon a physical interaction with Cas PMID: 15272013
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亞細(xì)胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, ruffle membrane.; [Isoform 1]: Cell membrane; Peripheral membrane protein.
組織特異性：

Expressed in the olfactory bulb and olfactory sensory neurons (at protein level). Expressed in B cells (at protein level). Expressed in T lymphocytes.; [Isoform 1]: Expressed in hematopoietic cells from spleen, lymph node and thymus (at protein level). Ex
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:27387

STRING: 10090.ENSMUSP00000073866

UniGene: Mm.474256