Recombinant Mouse SERTA domain-containing protein 2 (Sertad2)
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中文名稱：小鼠Sertad2重組蛋白
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貨號：CSB-EP888324MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：Sertad2
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Uniprot No.：
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別名：Sertad2; Kiaa0127; MNCb-1504; SERTA domain-containing protein 2; Transcriptional regulator interacting with the PHD-bromodomain 2; TRIP-Br2
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種屬：Mus musculus (Mouse)
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蛋白長度：full length protein
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表達區域：1-309
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氨基酸序列MLGKGGKRKF DEHEDGLEGK IVSPSDGPSR VSYTLQRQTI FNISLMKLYN HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPAFTPSS QPSNSLSDSY QEAPPPAPHP CDLGSTTPLE ACLTPASLLE DDNDDTFCTL QAVHPAAPTR LSSAALPAEK DSFSSALDEI EELCPTSTST EAAHTAAPEG PKGTSSESSV QKPEGPEEGR TDDSRFMDSL PGNFEITTST GFLTDLTLDD ILFADIDTSM YDFDPCTSAS GTASKMAPVS ADDLLKTLAP YSNQPVAPSQ PFKMDLTELD HIMEVLVGS
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
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基因功能參考文獻：
- Study demonstrates a role for TRIP-Br2 in endoplasmic reticulum stress-induced brown adipose tissue (BAT) dysfunction, and inhibiting TRIP-Br2 could be a potential approach for counteracting obesity-induced BAT dysfunction. PMID: 28067333
- Data suggest that expression of microRNA-128-3p is down-regulated during adipogenesis; an abundance of microRNA-128-3p appears to down-regulate adipogenesis and up-regulate lipolysis in adipocytes by targeting expression of Pparg (peroxisome proliferator-activated receptor gamma) and Sertad2 (SERTA domain-containing protein-2). PMID: 29654510
- Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat. PMID: 27109496
- TRIP-Br2, modulates fat storage through simultaneous regulation of lipolysis, thermogenesis and oxidative metabolism. PMID: 23291629
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亞細胞定位：Nucleus. Cytoplasm.
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組織特異性：Expressed in white and brown adipose tissue.
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