Recombinant Mouse Ribosomal protein S6 kinase alpha-5 (Rps6ka5), partial
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中文名稱：小鼠Rps6ka5重組蛋白
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貨號：CSB-EP805999MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Rps6ka5; Msk1Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; EC 2.7.11.1; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RLSK
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種屬：Mus musculus (Mouse)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes(PubMed:11553624, PubMed:11909979, PubMed:16806820). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury. Phosphorylates TRIM7 at 'Ser-106' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity.
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基因功能參考文獻：
- These data suggest that the kinase activity of MSK1 is not directly required for several forms of synaptic plasticity or spatial learning and memory. PMID: 28275711
- These data of this study provided important new insights into the mechanism by which the MAPK/MSK1 signaling cassette confers neuroprotection against excitotoxic insults. PMID: 28870089
- Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit) PMID: 29054929
- chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development PMID: 27973548
- abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter PMID: 25193242
- Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2. PMID: 26611568
- Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis PMID: 25451279
- MSK1 has a role in malignant transformation and skin cancer development, but is inhibited by chrysin derivative 69407 PMID: 24169959
- the impact of MSK1 on glucocorticoid receptor-mediated transactivation PMID: 23831393
- MSK1 is an important novel molecule involved in RANKL signaling and osteoclast differentiation PMID: 23619911
- MSK1/2 knockout results in reduced IL-10 secretion. PMID: 23382072
- MSK1-deficient mice exhibit a decreased capacity to entrain to a new light cycle, attenuated Period1 expression, histone phosporylation and CREB phosphorylation. PMID: 23127194
- these data reveal that MSK1 serves as a critical regulator of hippocampal physiology and function PMID: 23077336
- data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone PMID: 23020821
- This study demonstrated that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. PMID: 22993422
- by suppression of both NF-kappaB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation. PMID: 22733812
- MSK1 is an important downstream kinase involved in CS-induced NF-kappaB activation PMID: 22312446
- the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages PMID: 22004609
- Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells. PMID: 21970321
- phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggest that mouse MSK1 may play a key role in the metaphase-II arrest through phosphorylation of EMI2 PMID: 21924255
- MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation. PMID: 21166721
- MSK1 represents a pro-survival pathway bifurcating downstream of p38 and antagonizes the established pro-apoptotic p38 MAPK function. PMID: 21106525
- These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis. PMID: 21314333
- mechanism of immediate-early gene induction PMID: 21071437
- MSK1/2 regulate pri-miR-212/132 transcription via the phosphorylation of CREB. PMID: 20307261
- MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages PMID: 19922413
- Mycobacterium avium-induced cyclooxygenase-2 expression in mouse macrophages is regulated by TLR-2 and MSK1 PMID: 15496409
- findings suggested that MSK1/2 might play a critical role in the survival of lipopolysaccharide-stimulated RAW 264.7 cells PMID: 15681159
- MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation PMID: 16517600
- MSK1 is the critical mediator of differentiation-induced H3 phosphoacetylation PMID: 16728397
- MSK1 has a role downstream of p38 in the regulation of As2O3 responses PMID: 16762916
- Erk activation leads to phosphorylation of the progesterone receptor (PR), activation of Msk1, and recruitment of a complex of the three proteins to a nucleosome on the MMTV promoter. PMID: 17081988
- We conclude that adenylyl cyclase activity supports the activation of MAPK, and that MSK1 is the major CREB kinase activated during training for contextual memory. PMID: 17196532
- correlated to a reduction in the T-Cell Receptor-induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2-induced CREB phosphorylation PMID: 17668895
- Our study identifies MSK1 as an important regulator of chromatin remodeling in long-term memory. PMID: 18003853
- mitogen- and stress-activated kinase-1(MSK-1) deficiency is involved in transcriptional dysregulation and striatal degeneration PMID: 18029446
- the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1. PMID: 19015318
- The authors demonstrate that MSK1 phosphorylates RARalpha at S369 located in the ligand-binding domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H. PMID: 19078967
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亞細胞定位：Nucleus.
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蛋白家族：Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
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