Recombinant Mouse Ribosomal RNA-processing protein 8 (Rrp8)

中文名稱：

小鼠Rrp8重組蛋白
貨號：

CSB-YP872041MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rrp8重組蛋白
貨號：

CSB-EP872041MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rrp8重組蛋白
貨號：

CSB-EP872041MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rrp8重組蛋白
貨號：

CSB-BP872041MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rrp8重組蛋白
貨號：

CSB-MP872041MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rrp8
Uniprot No.：

Q9DB85
別名：

Rrp8; Ribosomal RNA-processing protein 8; EC 2.1.1.-; Cerebral protein 1 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-457
氨基酸序列

MFEEPEWVEA APAIVGLGAA TAQVRPATAP PVKGRKRRHL LATLRALEAA SLSQQTPSLP GSDSEEEEEV GRKKRHLQRP SLASVSKEVG KKRKGKCQKQ APSISDSEGK EIRRKCHRQA PPLGGVSAGE EKGKRKCQEY SSLHLTQPLD SVDQTVHNSR TSTATIDPSK PSPESMSPNS SHTLSRKQWR NRQKNKRRHK NKFRPLQTPE QAPPKASIEE TEVPPVPKSD SQESRAGALR ARMTQRLDGA RFRYLNEQLY SGPSSAARRL FQEDPEAFLL YHRGFQRQVK KWPLHPVDRI AKDLRQKPAS LVVADFGCGD CRLASSVRNP VHCFDLASLD PRVTVCDMAQ VPLEDESVDV AVFCLSLMGT NIRDFLEEAN RVLKTGGLLK VAEVSSRFED IRTFLGAVTK LGFKIIYKDL TNSHFFLFDF EKTGPPRVGP KAQLSGLKLQ PCLYKRR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
基因功能參考文獻：
1. The suppression of p53 did not rescue the lethality or impaired erythropoiesis of NML-/- embryos, suggesting that p53-independent mechanisms underlie the NML-deficient phenotypes. PMID: 29244083
亞細胞定位：

Nucleus, nucleolus.
蛋白家族：

Methyltransferase superfamily, RRP8 family
數據庫鏈接：

KEGG: mmu:101867

STRING: 10090.ENSMUSP00000095752

UniGene: Mm.231400