Recombinant Mouse Rho GTPase-activating protein 32 (Arhgap32), partial

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 32(Arhgap32) ,partial
貨號：

CSB-YP767379MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 32(Arhgap32) ,partial
貨號：

CSB-EP767379MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 32(Arhgap32) ,partial
貨號：

CSB-EP767379MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 32(Arhgap32) ,partial
貨號：

CSB-BP767379MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 32(Arhgap32) ,partial
貨號：

CSB-MP767379MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Arhgap32
Uniprot No.：

Q811P8
別名：

Arhgap32; Grit; Kiaa0712; Rics; Rho GTPase-activating protein 32; Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; p200RhoGAP; p250GAP
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.
基因功能參考文獻：
1. Our results suggest that PX-RICS-mediated GABAAR trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism. PMID: 30045817
2. PX-RICS-deficient mice exhibit ASD-like social behaviours and ASD-related comorbidities. PX-RICS-deficient neurons show reduced surface gamma-aminobutyric acid type A receptor (GABAAR) levels and impaired GABAAR-mediated synaptic transmission. PMID: 26979507
3. leptin stimulates the MAPK pathways and CREB dependent transcription. This then leads to an increase in miR132 that suppresses expression of the Rac1 inhibitor p250GAP, thus activating Rac1 and promoting synaptogenesis. PMID: 24877561
4. Overexpression of p250GAP abolishes brain-derived neurotrophic factor (BDNF)-induced branching. PMID: 24431455
5. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain PMID: 23226367
6. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases [RICS] PMID: 12531901
7. RICS plays an important role in neurite extension PMID: 16716191
8. p200 RhoGAP can mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation PMID: 17272280
9. These results suggest that PX-RICS is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits. PMID: 17663722
10. p250GAP plays an important role in NMDA receptor-mediated regulation of RhoA activity leading to spine morphological plasticity. PMID: 18331582
11. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling. PMID: 18451111
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亞細胞定位：

Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane.
蛋白家族：

PX domain-containing GAP family
組織特異性：

Isoform 1 and isoform 2 are highly expressed in brain, specially in cortex, corpus striatum, hippocampus and thalamus. Low levels in cerebellum, colon, small intestine, and kidney.
數據庫鏈接：

KEGG: mmu:330914

STRING: 10090.ENSMUSP00000133898

UniGene: Mm.46683