Recombinant Mouse Rho GTPase-activating protein 24 (Arhgap24)

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 24(Arhgap24)
貨號(hào)：

CSB-YP805397MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 24(Arhgap24)
貨號(hào)：

CSB-EP805397MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 24(Arhgap24)
貨號(hào)：

CSB-EP805397MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 24(Arhgap24)
貨號(hào)：

CSB-BP805397MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 24(Arhgap24)
貨號(hào)：

CSB-MP805397MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Arhgap24
Uniprot No.：

Q8C4V1
別名：

Arhgap24; Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-747
氨基酸序列

MEERCESTES PQGQGRKNTK CGWLRKQGGF VKTWHTRWFV LKGDQLYYFK DEDETKPLGT IFLHGNKVIE HPCNEENPGK FLFDVVPGGE RDRMTANHES YLLMASTQND MEDWVKSIRR VIWGPFGGGI FGQKLEDTVR YEKRYGNRLA PMLVEQCVDF IRQRGLKEEG LFRLPGQANL VKELQDAFDC GEKPSFDSNT DVHTVASLLK LYLRELPEPV VPYAKYEDFL SCATLLSKEE EAGVKELMKQ VKSLPVVNYN LLKYICRFLD EVQSYSGVNK MSAQNLATVF GPNILRPKVE DPLTIMEGTV VVQQLMSVMI SKHDRLFPKD TEPQSKPQDG PNSNNNDGHK KATMGQLQNK ENNNTKESPV RRCSWDKPES PQRSSVDNGS PTALSGSKTN SPRNSIHKLD ISRSPPLMVK KNPAFNKGSG IVTNGSFSSS NAEGVEKPQT TPNGSLQARR TSSLKSSGTK MGTHSVQNGT VRMGILNTDT LGNSLNGRSM SWLPNGYVTL RDNKQKEPAG ESGQHNRLST YDNVHQQFSS MSLDDKHSVD SATWSTSSCE ISLPENSNSC RSSTTTCPEQ DFYVGNFEDP VLDGPPQDDL SHPGDYENKS DRRSVGGRSS RATSSSDNSE TFVGNTSSNH SALHSLVSSL KQEMTKQKIE YESRIKSLEQ RNLTLETEML SLHDELDQER KKFTMIEIKM RNAERAKEDA EKRNDMLQKE MEQFFSTFGD LTVEPRRSER GNTIWIQ
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
基因功能參考文獻(xiàn)：
1. Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics. PMID: 21911940
亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection.
數(shù)據(jù)庫鏈接：

KEGG: mmu:231532

STRING: 10090.ENSMUSP00000092138

UniGene: Mm.440191