Recombinant Mouse Putative histone-lysine N-methyltransferase PRDM6 (Prdm6)

中文名稱：

小鼠Prdm6重組蛋白
貨號：

CSB-YP663692MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Prdm6重組蛋白
貨號：

CSB-EP663692MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Prdm6重組蛋白
貨號：

CSB-EP663692MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Prdm6重組蛋白
貨號：

CSB-BP663692MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Prdm6重組蛋白
貨號：

CSB-MP663692MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Prdm6
Uniprot No.：

Q3UZD5
別名：

Prdm6; Gm92; Prism; Putative histone-lysine N-methyltransferase PRDM6; EC 2.1.1.361; PR domain zinc finger protein 6; PR domain-containing protein 6; PR domain-containing protein in smooth muscle
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-596
氨基酸序列

MLKPGDPGGS AFLKVDPAYL QHWQQLFPHG GGGGGPLKAS GAALALGAPQ PLQPPPPPPP PPPERAEPPP DGLRPRPASL SSTPAPSSTS ASSASSCAAA AAAAALAGLS ALPVAQMPVF APLAAAAVAA EPLPPKDLCL GASAGPGPAK CGGGGGSVGD GRGVPRFRCS AEELDYYLYG QQRMEIIPLN QHTSDPNNRC DMCADNRNGE CPMHGPLHSL RRLVGTSSAA AAAPPPELPE WLRDLPREVC LCTSTVPGLA YGICAAQRIQ QGTWIGPFQG VLLSPEKVQT GVVRNTQHLW EIYDQDGTLQ HFIDGGEPSK SSWMRYIRCA RHCGEQNLTV VQYRSNIFYR ACIDIPRGTE LLVWYNDSYT SFFGIPLQCI AQDENLNVPS TVMEAMCRQD ALQPFNKSSK LSPSGQQRSV VFPQTPCSRN FSLLDKSGPM EAGFNQINVK NQRVLASPTS TSQLHSEFSD WHLWKCGQCF KTFTQRILLQ MHVCTQNPDR PYQCGHCSQS FSQPSELRNH VVTHSSDRPF KCGYCGRAFA GATTLNNHIR THTGEKPFKC ERCERSFTQA TQLSRHQRMP NECKPITESP ESIEVD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
基因功能參考文獻：
1. identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development PMID: 24278461
2. PRISM acts as a novel epigenetic regulator of Smooth Muscle Cells (SMC) phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs. PMID: 16537907
3. These data indicate that PRDM6 is expressed by vascular precursors, has differential effects in endothelial cells and smooth muscle cells, and may play a role in vascular precursor differentiation and survival. PMID: 17662997
亞細胞定位：

Nucleus.
蛋白家族：

Class V-like SAM-binding methyltransferase superfamily
組織特異性：

Expressed in a variety of smooth muscle-containing tissues and displays especially robust expression in the cardiac outflow tract and descending aorta during embryogenesis. Also enriched in vascular precursors during development.
數據庫鏈接：

KEGG: mmu:225518

STRING: 10090.ENSMUSP00000089513

UniGene: Mm.297645