Recombinant Mouse Protein canopy homolog 3 (Cnpy3)

中文名稱：

Recombinant Mouse Protein canopy homolog 3(Cnpy3)
貨號：

CSB-YP863570MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Protein canopy homolog 3(Cnpy3)
貨號：

CSB-EP863570MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Protein canopy homolog 3(Cnpy3)
貨號：

CSB-EP863570MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Protein canopy homolog 3(Cnpy3)
貨號：

CSB-BP863570MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Protein canopy homolog 3(Cnpy3)
貨號：

CSB-MP863570MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cnpy3
Uniprot No.：

Q9DAU1
別名：

Cnpy3; Prat4a; Tnrc5Protein canopy homolog 3; Protein associated with Tlr4; Trinucleotide repeat-containing gene 5 protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

27-276
氨基酸序列

APKL GPSPAGAEET DWVRLPSKCE VCKYVAVELK SAFEETGKTK EVIDTGYGIL DGKGSGVKYT KSDLRLIEVT ETICKRLLDY SLHKERTGSN RFAKGMSETF ETLHNLVHKG VKVVMDIPYE LWNETSAEVA DLKKQCDVLV EEFEEVIEDW YRNHQEEDLT EFLCANHVLK GKDTSCLAER WSGKKGDIAS LGGKKSKKKR SGVKGSSSGS SKQRKELGGL GEDANAEEEE GVQKASPLPH SPPDEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
基因功能參考文獻：
1. association with PRAT4A is required for ligand-induced trafficking of TLR9 to endolysosomes PMID: 19120473
2. Cell surface expression of TLR5 is dependent on PRAT4A and restricted to neutrophils, classical monocytes and specific DC subsets. PMID: 22836022
3. Data suggest that CNPY3 interacts with the ATP-sensitive conformation of gp96 to promote substrate loading. Our study has thus established CNPY3 as a TLR-specific cochaperone for gp96. PMID: 20865800
4. PRAT4A is a novel protein associated with toll-like receptor (TLR) 4 that regulates cell surface expression of receptor complex TLR4/MD-2. PMID: 16849487
5. PRAT4A regulates the subcellular distribution and response of multiple toll-like recaptors and is required for both innate and adaptive immune responses PMID: 17998391
6. single base mutant associates preferentially with TLR9, and differentially interacts with TLR2, 4 and 9 PMID: 18780723
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亞細胞定位：

Endoplasmic reticulum.
蛋白家族：

Canopy family
數據庫鏈接：

KEGG: mmu:72029

STRING: 10090.ENSMUSP00000050309

UniGene: Mm.240325