Recombinant Mouse Protein Hook homolog 1 (Hook1)

中文名稱：

小鼠Hook1重組蛋白
貨號：

CSB-YP807360MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hook1重組蛋白
貨號：

CSB-EP807360MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hook1重組蛋白
貨號：

CSB-EP807360MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hook1重組蛋白
貨號：

CSB-BP807360MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hook1重組蛋白
貨號：

CSB-MP807360MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hook1
Uniprot No.：

Q8BIL5
別名：

Hook1; Protein Hook homolog 1; mHK1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-728
氨基酸序列

MEDPQPLPQS ELPLCDSLII WLQTFKTASP CQDVKQLTNG VTMAQVLHQI DVAWFSESWL SRIKDDVGDN WRIKASNLKK VLHGITSYYH EFLGQQISEE LIPDLNQITE CADPVELGRL LQLILGCAVN CEKKQEHIKN IMTLEESVQH VVMTAIQELM SKEIVISPAS DTVGELEQQL KRALEELQEA IAEKEELKQR CQELDMQVTT LQDEKNSLVS ENEMMNEKLD QLDGSFDDPN TMVAKKYFHV QLQLEQLQEE NYRLEAAKDD YRVHCEELEK QLIEFQHRND ELTSLAEETR ALKDEIDVLR ATSDKANKLE STVEVYRQKL QDLNDLRKQV KSLQETNMMY MHNTVSLEEE LKKANAARAQ LETYKRQVQD LHTKLSSESK RADTLAFEMK RLEEKHETLL KEKERLIEQR DTLKETNEEL RCSKAQQDHL NQADASATKS YENLAAEIMP VEYREVFIRL QHENKMLRLQ QEGTENERIE QLQEQLEQKH RKMNELETEQ RLSKERIGEL QQQIEDLQKS LQEQGSKSEG ESSSKLKQKL EAHMEKLTEV HEELQKKQEL IEDLQPDISQ NAQKISELEA ALQKKDEDMK AMEERYKMYL EKARNVIKTL DPKLNPASAE IMLLRKQLAE KERRIEILES ECKVAKLRDY EEKLIVSAWY NKSLAFQKLG MESRLVSGAS ACKDSVAAAP ARSFLAQQRH ITNTRRNLSV KVPAAASD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton.
基因功能參考文獻：
1. Hook1 is a binding partner of Ccdc181. PMID: 28283191
2. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). PMID: 27365401
3. azh mutation is due to a deletion of exons 10 and 11 in the murine Hook1 gene leading to a non-functional protein. Our results indicate that loss of Hook1 function results in ectopic positioning of microtubular structures within the spermatid PMID: 12075009
4. Hook1 and Ankyrin G are co-locolized, Hook1 also localizes to additional regions of the cell devoid of Ankyrin G where it interacts with other proteins. PMID: 15823567
5. Multiple samples of ejaculated spermatozoa from normal fertile C57BL/6 and infertile Hook1/Hook1 (formerly known as azh/azh) mutant males from uteri after mating. PMID: 17314312
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相關疾病：

Defects in Hook1 are the cause of the azh (abnormal spermatozoon head shape) mutant phenotype, which induces spermatozoa with highly abnormal head morphology that differs drastically from the compact and hook-shaped head of the normal sperm, leading to a strong decrease of fertility.
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton.
蛋白家族：

Hook family
組織特異性：

Mainly expressed in testis.
數據庫鏈接：

KEGG: mmu:77963

STRING: 10090.ENSMUSP00000030306

UniGene: Mm.49994