Recombinant Mouse Protein DEK (Dek)

中文名稱：

Recombinant Mouse Protein DEK(Dek)
貨號：

CSB-YP766504MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Protein DEK(Dek)
貨號：

CSB-EP766504MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Protein DEK(Dek)
貨號：

CSB-EP766504MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Protein DEK(Dek)
貨號：

CSB-MP766504MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dek
Uniprot No.：

Q7TNV0
別名：

DekProtein DEK
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-380
氨基酸序列

MSAAAAPAAE GEDAPVPPSS EKEPEMPGPR EESEEEEEDD EDDDEEDEEE EKEKSLIVEG KREKKKVERL TMQVSSLQRE PFTVTQGKGQ KLCEIERIHF FLSKKKPDEL RNLHKLLYNR PGTVSSLKKN VGQFSGFPFE KGSTQYKKKE EMLKKFRNAM LKSICEVLDL ERSGVNSELV KRILNFLMHP KPSGKPLPKS KKSSSKGSKK ERNSSGTTRK SKQTKCPEIL SDESSSDEDE KKNKEESSED EEKESEEEQP PKKTSKKEKA KQKATAKSKK SVKSANVKKA DSSTTKKNQK SSKKESESED SSDDEPLIKK LKKPPTDEEL KETVKKLLAD ANLEEVTMKQ ICKEVYENYP AYDLTERKDF IKTTVKELIS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in chromatin organization.
基因功能參考文獻：
1. These findings define DEK as an important and multifunctional mediator of homologous recombination. PMID: 28317934
2. DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy. PMID: 28165452
3. DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex. PMID: 29175155
4. Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth. PMID: 29538372
5. Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage. PMID: 29109007
6. DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation PMID: 25128083
7. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
8. Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas. PMID: 25049225
9. data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector PMID: 24608431
10. DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest. PMID: 21943234
11. The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein. PMID: 20827285
12. DEK is a neuroblastoma tumor antigen. PMID: 17397536
13. Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes. PMID: 17524367
14. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. PMID: 19223548
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: mmu:110052

STRING: 10090.ENSMUSP00000021807

UniGene: Mm.131150