Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2)

中文名稱：

小鼠Pstpip2重組蛋白
貨號(hào)：

CSB-YP859980MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Pstpip2重組蛋白
貨號(hào)：

CSB-EP859980MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Pstpip2重組蛋白
貨號(hào)：

CSB-EP859980MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pstpip2重組蛋白
貨號(hào)：

CSB-BP859980MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pstpip2重組蛋白
貨號(hào)：

CSB-MP859980MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pstpip2
Uniprot No.：

Q99M15
別名：

Pstpip2; Mayp; Proline-serine-threonine phosphatase-interacting protein 2; PEST phosphatase-interacting protein 2; Macrophage actin-associated tyrosine-phosphorylated protein; pp37
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-334
氨基酸序列

TGSLFKGNF WSTDILSTIG YDSIIQHLNN GRKNCKEFED FLKERASIEE KYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQTLRE EARKMEEFRE KQKLQRKKTE TIMDAAHKQR NAQFKKAMDA KKNYEQKCRD KDEAEQAVHR SANVANQRQQ EKLFVKLATS KTAVEDSDKA YMLHINMLEK VREDWQSEHI KACEVFEAQE CERINFFRNA LWLHLNQLSQ QCVANDEMYE QVRKSLETCS IEKDIQYFVN QRKTGQTPPA PIMYENFYSP QRNAAPPGKT TGPNPARRGP LPVPKRIPDD PDYSVVEDYS LLYQ
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
基因功能參考文獻(xiàn)：
1. PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome. PMID: 25602062
2. Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17, leading to'hyperactivation' of actin nucleation at podosomes and ECM degradation. PMID: 23525018
3. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. PMID: 22923495
4. our pstpip2 mutant mice provide a new model for investigating the potential mechanisms of inflammatory pain. PMID: 22646813
5. MAYP directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. PMID: 15788569
6. A missense mutation in pstpip2 is associated with the autoinflammatory disorder chronic multifocal osteomyelitis. PMID: 16122996
7. mutations are associated with spontaneous disease in mouse model of osteomyelitis PMID: 18721907
8. PSTPIP2 deficiency leads to autoinflammatory disease. PMID: 19608749
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亞細(xì)胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
組織特異性：

Expressed in macrophage-containing tissues, including bone marrow, spleen, liver, kidney, intestine and brain.
數(shù)據(jù)庫鏈接：

KEGG: mmu:19201

STRING: 10090.ENSMUSP00000110389

UniGene: Mm.57174