Recombinant Mouse Potassium voltage-gated channel subfamily E member 2 (Kcne2), partial

中文名稱：

小鼠Kcne2重組蛋白
貨號：

CSB-YP861567MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Kcne2重組蛋白
貨號：

CSB-EP861567MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Kcne2重組蛋白
貨號：

CSB-EP861567MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Kcne2重組蛋白
貨號：

CSB-BP861567MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Kcne2重組蛋白
貨號：

CSB-MP861567MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Kcne2
Uniprot No.：

Q9D808
別名：

Kcne2; Potassium voltage-gated channel subfamily E member 2; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current.
基因功能參考文獻：
1. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM. PMID: 28280005
2. Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury PMID: 26952045
3. The data establish causality for the first example of ion channel-linked atherosclerosis, and demonstrate that the severity of Kcne2-linked cardiac arrhythmias is strongly diet-dependent. PMID: 26307149
4. Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration. PMID: 26297229
5. Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia. PMID: 25127743
6. KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability. PMID: 24595108
7. The Kcne2 Deletion suggest that a more holistic view of the pathogenesis of monogenic cardiac arrhythmias could provide a clearer picture of the mechanisms underlying sudden cardiac dealth. PMID: 24403551
8. KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells. PMID: 23504710
9. Loss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop. PMID: 22880098
10. KCNE2 influences blood-CSF anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium. PMID: 21859894
11. The results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia. PMID: 20625512
12. KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function. PMID: 16754665
13. Targeted disruption of kcne2 has revealed a novel cardiac partner for MiRP1, a novel role for MiRPs in alpha subunit targeting in vivo, and a role for MiRP1 in murine ventricular repolarization with parallels to that proposed for the human heart. PMID: 18603586
14. Cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy. PMID: 18611433
15. we describe the transcription profiles of the four HCN genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse. PMID: 19421833
16. KCNE2 serves as a regulatory beta-subunit of Hyperpolarization-activated cation channels PMID: 19429827
17. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. PMID: 19767733
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Potassium channel KCNE family
數(shù)據(jù)庫鏈接：

KEGG: mmu:246133

STRING: 10090.ENSMUSP00000048849

UniGene: Mm.156736