Recombinant Mouse Poly [ADP-ribose] polymerase 14 (Parp14), partial

中文名稱：

小鼠Parp14重組蛋白
貨號：

CSB-YP641916MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Parp14重組蛋白
貨號：

CSB-EP641916MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Parp14重組蛋白
貨號：

CSB-EP641916MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Parp14重組蛋白
貨號：

CSB-BP641916MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Parp14重組蛋白
貨號：

CSB-MP641916MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Parp14
Uniprot No.：

Q2EMV9
別名：

Parp14; Kiaa1268; Protein mono-ADP-ribosyltransferase PARP14; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; Collaborator of STAT6; CoaSt6; Poly [ADP-ribose] polymerase 14; PARP-14
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9.
基因功能參考文獻：
1. PARP14 has an intrinsic role in Th2 cytokine control to limit the severity of allergic skin disease. PMID: 28653395
2. these studies demonstrate that PARP-14 regulates multiple cytokine responses during inflammatory immunity. PMID: 26222149
3. study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14. PMID: 25293769
4. PARP-14 is an important factor for T helper cell differentiation and it binds to specific DNA sequences to mediate its function. PMID: 24376650
5. findings show that PARP14 influences the class distribution, affinity repertoire, and recall capacity of Ab responses in mice PMID: 23956424
6. PARP-14-deficient animals show reduced lung pathology. PMID: 22841009
7. Data suggest that the PARP14-dependent capacity to increase cellular metabolic rates may be an important determinant of lymphoma pathobiology. PMID: 21911376
8. in the presence of IL-4 the catalytic activity of PARP-14 facilitates Stat6 binding to the promoter, and release of HDACs so as to activate transcription. PMID: 21081493
9. Stat6 binds to collaborator of Stat6 (CoaSt6), a protein that lacks conventional coactivator motifs but contains three iterations of a domain found in the variant histone macroH2A. PMID: 16537510
10. PARP enzymatic activity is associated with CoaSt6, and this function of CoaSt6 can append ADP-ribose to itself and p100 PMID: 17478423
11. Data show that Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. PMID: 18069692
12. PARP-14 mediates regulation of gene expression and lymphocyte physiology by IL-4 and has a function distinct from PARP-1. PMID: 19147789
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亞細胞定位：

Nucleus. Cytoplasm.
組織特異性：

Weakly expressed in the thymus during development and in adulthood. Expressed in macrophages.
數據庫鏈接：

KEGG: mmu:547253

STRING: 10090.ENSMUSP00000037657

UniGene: Mm.244406