Recombinant Mouse Pleckstrin homology domain-containing family O member 1 (Plekho1)

中文名稱：

小鼠Plekho1重組蛋白
貨號：

CSB-YP867492MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Plekho1重組蛋白
貨號：

CSB-EP867492MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Plekho1重組蛋白
貨號：

CSB-EP867492MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Plekho1重組蛋白
貨號：

CSB-BP867492MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Plekho1重組蛋白
貨號：

CSB-MP867492MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Plekho1
Uniprot No.：

Q9JIY0
別名：

Plekho1; Pleckstrin homology domain-containing family O member 1; PH domain-containing family O member 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-408
氨基酸序列

MKKSGSGKRG PPDGNHQSAA PEKVGWVRKF CGKGIFREIW KNRYVVLKGD QLYVSEKEVK DEKNSQEVFD LSDYEKCEEL RKSKSRSKKN HSKFTLARCR QPGTTAPNLI FLAVSPEEKE SWINALSSAI TRAKNRILDE VTVEEDSYLA HPTRDRAKIQ HSRRPPTRGH LMAVASTSTS DGMLTLDLIQ EEDPSPEEPA SCAESFRVDL DKSVAQLAGS RRRADSDRIQ PSSQRASSLS RPWEKPDKGA PYTPQALKKF PSTEKSRCAS LEEILSQRDT APARPLHLQA EESLPPVPAQ PGQLSRIQDL VARKLEKTQE LLAEVQGLGD GKRKAKDPPQ SPPDSESEQL LLETERLLGE ASSNWSQAKR VLQEVRELRD LYRQMDLQTP DSHLRQTSQH SQYRKSLM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
基因功能參考文獻：
1. The aim of this study was to investigate the effect of constrained dynamic loading (Loading) in combination with CKIP1 gene knockout (KO) on unloadinginduced bone loss in tailsuspension mice. PMID: 29956799
2. the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression PMID: 28128304
3. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. PMID: 28404913
4. PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 PMID: 28286065
5. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. PMID: 28212865
6. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 phosphorylation and further upregulating IRS-1 phosphorylation and RI. PMID: 28351752
7. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. PMID: 28083909
8. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1) and fibronectin plus activation of Nrf2/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway. PMID: 27481061
9. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis PMID: 27666961
10. CKIP-1 is a novel inhibitor of MSC-originated adipogenesis by enhancing HDAC1-associated repression of C/EBPalpha. PMID: 25240053
11. CKIP-1 interacts with TRAF6, a ubiquitin ligase required for K63-linked ubiquitination and plasma membrane recruitment of Akt, and terminates TRAF6-mediated Akt activation. PMID: 24777252
12. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration. PMID: 23747421
13. CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A. PMID: 23151343
14. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
15. CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1. PMID: 18641638
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亞細胞定位：

Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.
數據庫鏈接：

KEGG: mmu:67220

STRING: 10090.ENSMUSP00000015889

UniGene: Mm.458147