Recombinant Mouse Plasma cell-induced resident endoplasmic reticulum protein (Pacap)

中文名稱：

小鼠Mzb1重組蛋白
貨號(hào)：

CSB-YP875237MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Mzb1重組蛋白
貨號(hào)：

CSB-EP875237MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Mzb1重組蛋白
貨號(hào)：

CSB-EP875237MO-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mzb1重組蛋白
貨號(hào)：

CSB-BP875237MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Mzb1重組蛋白
貨號(hào)：

CSB-MP875237MO
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mzb1
Uniprot No.：

Q9D8I1
別名：

Mzb1; Pacap; Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

21-188
氨基酸序列

GDRVSLSASA PTLDDEEKYS AHMPAHLRCD ACRAVAFQMG QRLAKAEAKS HTPDASGLQE LSESTYTDVL DQTCSQNWQS YGVHEVNQMK RLTGPGLSKG PEPRISVMIS GGPWPNRLSK TCFHYLGEFG EDQIYEAYRQ GQANLEALLC GGTHGPCSQE ILAQREEL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
基因功能參考文獻(xiàn)：
1. Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes. PMID: 30257949
2. MZB1 seems to act as a substrate-specific cochaperone of GRP94 that enables proper biosynthesis of microHCs under conditions of ER stress. PMID: 24888588
3. miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID: 24014023
4. In a mouse model of asthma 2010001M09Rik (Mzb1) was unaltered 24 hours after allergen exposure, however, by 72 hours a marked increase in 2010001M09Rik mRNA was detected in lung tissue from disease-susceptible C57BL/6 and BALB/c mice. PMID: 19395375
5. Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation. PMID: 21093319
6. Data suggest that pERp1 is either a unique type of oxidoreductase or a previously unidentified class of molecular chaperone that is dedicated to enhancing the oxidative folding of Ig precursors. PMID: 19805157
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亞細(xì)胞定位：

Endoplasmic reticulum. Endoplasmic reticulum lumen. Secreted.
蛋白家族：

MZB1 family
組織特異性：

Expressed predominantly in the spleen and lymph nodes. Abundantly expressed in marginal zone B and B1 cells. High expression in mesenteric adipose tissue (MAT). Expressed also in pancreas, perigonadal adipose tissue (PAT), uterus, subcutaneous adipose tis
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:69816

STRING: 10090.ENSMUSP00000025211

UniGene: Mm.27252