Recombinant Mouse Placenta-expressed transcript 1 protein (Plet1)

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中文名稱：

小鼠Plet1重組蛋白
貨號：

CSB-EP851843MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Plet1
Uniprot No.：

Q8VEN2
別名：

Plet1; Placenta-expressed transcript 1 protein; Antigen mAgK114
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

36.1kDa
表達區域：

28-218aa
氨基酸序列

SDNGSCVVLDNIYTSDILEISTMANVSGGDVTYTVTVPVNDSVSAVILKAVKEDDSPVGTWSGTYEKCNDSSVYYNLTSQSQSVFQTNWTVPTSEDVTKVNLQVLIVVNRTASKSSVKMEQVQPSASTPIPESSETSQTINTTPTVNTAKTTAKDTANTTAVTTANTTANTTAVTTAKTTAKSLAIRTLGS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

小鼠胎盤表達轉錄本1蛋白（Plet1）是一種在胎盤中表達的蛋白質，其在小鼠的滋養層細胞命運決定中具有潛在作用。這種蛋白質的表達可能參與細胞-基質粘附的負調控、細胞遷移的正調控以及傷口愈合，表皮細胞的擴散。在科研方向，Plet1可應用于以下幾個方向：
① 功能研究，Plet1是一種在胎盤中表達的蛋白質，其在小鼠滋養層細胞的命運決定中發揮了重要作用。科學家們已經開始評估Plet1在調節滋養層細胞身份形成和調控滋養層分化方面的功能。

② 組織修復，Plet1還參與了細胞-基質粘附的負調控、細胞遷移的正調控以及傷口愈合過程中表皮細胞的擴散。

③ 細胞表面蛋白，Plet1是一種表膜蛋白，它在小鼠和豬的胎盤中表達，并在胚胎外胚層、泌尿生殖系統、腸道、肺等結構中表達。

④ 細胞遷移，小腸中的小鼠CD11b+CD103+ DCs表達Plet1，這是一種糖磷脂酰肌醇(GPI)錨定的表面蛋白，參與角質細胞在創傷愈合期間的遷移。

華美生物提供大腸桿菌表達系統制備的全長小鼠Plet1重組蛋白，具備高純度、高穩定性等特點，助您進行相關科研工作。
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
基因功能參考文獻：
1. The endogenous dynamics of Plet1 expression establish important patterning cues within the trophoblast compartment by promoting differentiation towards the syncytiotrophoblast or giant cell pathway in Plet1-low and Plet1-high cells, respectively. PMID: 27121762
2. these results show that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis PMID: 29070673
3. The restricted localization in both differentiated outer root sheath and companion layer cells contacting the hair fiber and epidermal wounds suggests a role for the Plet-1 protein in regulating the interaction of keratinocytes with inert tissues. PMID: 20130590
4. Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems PMID: 18195351
亞細胞定位：

Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.
組織特異性：

Present in hair follicle cells and sebaceous gland of skin, ciliated epithelial cells of trachea and bronchial tube, striated portion of submandibular gland, distal convoluted tubule cells of kidney, ciliated epithelial cells of oviduct, medulla of adrena
數據庫鏈接：

KEGG: mmu:76509

STRING: 10090.ENSMUSP00000110118

UniGene: Mm.29959