Recombinant Mouse Piezo-type mechanosensitive ion channel component 2 (Piezo2), partial

中文名稱：

小鼠Piezo2重組蛋白
貨號：

CSB-YP804942MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Piezo2重組蛋白
貨號：

CSB-EP804942MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Piezo2重組蛋白
貨號：

CSB-EP804942MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Piezo2重組蛋白
貨號：

CSB-BP804942MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Piezo2重組蛋白
貨號：

CSB-MP804942MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Piezo2
Uniprot No.：

Q8CD54
別名：

Piezo2; Fam38b; Piezo-type mechanosensitive ion channel component 2; Protein FAM38B
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.
基因功能參考文獻：
1. Study establishes the role of epithelial Piezo2 mechanosensitive ion channels in regulation of intestinal physiology. PMID: 30037999
2. Targeted genetic deletion of Merkel cells and associated mechanosensitive Piezo2 channels in the skin was sufficient to produce alloknesis. PMID: 29724954
3. Study demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants. PMID: 29212024
4. Data provide evidence that Piezo2 plays a critical role in a defined homogeneous population of proprioceptor neurons that innervate the head muscles, demonstrating that this ion channel is essential for mammalian proprioceptive mechanotransduction. PMID: 27184818
5. Data show that Piezo2 knockdown led to decreased glioma angiogenesis and reduced vascular hyperpermeability. PMID: 27329839
6. experiments demonstrate a role for Pericentrin in modulating Piezo2 activity and membrane expression in somatosensory neurons PMID: 27345391
7. Enterochromaffin cells in the human and mouse small bowel GI epithelium selectively express the mechanosensitive ion channel Piezo2, and also that activation of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal secretion PMID: 27392819
8. Piezo2 is an airway stretch sensor; Piezo2-mediated mechanotransduction within various airway-innervating sensory neurons is critical for establishing efficient respiration at birth and maintaining normal breathing in adult mice PMID: 28002412
9. lysine substitution of E2416 alters conductance, ion selectivity and pore block of the channel PMID: 26008989
10. mice lacking Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation PMID: 25471886
11. engineered mice deficient in Piezo2 in the skin, but not in sensory neurons, show that Merkel-cell mechanosensitivity completely depends on Piezo2 PMID: 24717433
12. piezo2 sensitization may contribute to PKA- and PKC-mediated mechanical hyperalgesia. PMID: 22921401
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

PIEZO (TC 1.A.75) family
組織特異性：

Expressed in bladder, colon, and lung, but less abundant in kidney or skin. Strong expression is observed in dorsal root ganglia (DRG) sensory neurons. Expressed in a wide range of cutaneous low-threshold mechanoreceptors (LTMRs), including Merkel cells a
數據庫鏈接：

KEGG: mmu:667742

STRING: 10090.ENSMUSP00000040019

UniGene: Mm.158720