Recombinant Mouse Phosphoinositide 3-kinase regulatory subunit 6 (Pik3r6)

中文名稱：

小鼠Pik3r6重組蛋白
貨號：

CSB-YP664932MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pik3r6重組蛋白
貨號：

CSB-EP664932MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pik3r6重組蛋白
貨號：

CSB-EP664932MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pik3r6重組蛋白
貨號：

CSB-BP664932MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pik3r6重組蛋白
貨號：

CSB-MP664932MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pik3r6
Uniprot No.：

Q3U6Q4
別名：

Pik3r6; Phosphoinositide 3-kinase regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-756
氨基酸序列

MESSDVELDF QRSVQAVLRE LNTPNPALQS NQGMWRWSLH KKVERNPGKS SILVRILLRE LEKAESEDGR RVIIPLLLTL MSVLTKATGI PEDLYHRAYT FCTRLLTLPA PYSTVALDCA IRLKTETAVP GTLYQRTVIA EQNLISELYP YQERVFLFVD PELVSASVCS ALLLEIQAAQ EQQTPEACMR HVVSHALQAA LGEACHTGAL NRKLQASSRR VLEYYFHAVV AAIEQVASED SPSRLGHLEK MEEIYCSLLG PATTRRHCVG DLLQDRLPSI PLPSPYITFH LWTDQEQLWK ELVLFLRPRS QLRLSADLDA LDLQGFRLDR DLARVSTDSG IERDLPLGSD ELPDPSSSEM ERAALQRKGG IKKRVWPPDF FMPGSWDGPP GLHRRTGRPS GDGELLPGVS RVHTARVLVL GDDRMLGRLA QAYYRLRKRE TKKFCLTPRL SLQLYYIPVL APQVTGQDPE ASRKPELGEL ASFLGRVDPW YESTVNTLCP AILKLAEMPP YLDTSRTVDP FILDVITYYV RMGTQPIYFQ LYKVKIFTSL SHDPTEDIFL TELKVKIQDS KSPKEGSSPR RRGAAEGTGA ELSMCYQKAL LSHRPREVTV SLRATGLVLK AIPAGDTEVS GFFHCTSPNA ASATDCSCLH VSVTEVVKSS NLAGRSFTTS TNTFRTSSIQ VQSQDQRLLT LWLDKDGRRT FRDVVRFEVS PCPEPCSRTQ KSKTSALNSH GQETEKNMAK PNSLLMPINT FSGIIQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
基因功能參考文獻：
1. These data demonstrate PI3Kgamma-dependent signalling downstream of IL-17RA, which plays a pivotal role in regulating IL-17 production in T cells. PMID: 22930133
2. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. PMID: 22728827
3. that genetic deletion of PI3Kgamma enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2)-dependent itch. PMID: 22168443
4. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] PMID: 16476736
5. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells PMID: 18323525
6. PI3Kgamma has a role in the induction of CXCR3 on T cells PMID: 18658026
7. Results suggest that the CXCR2 and PI3Kgamma signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage. PMID: 19255141
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亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein.
組織特異性：

Highly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils.
數據庫鏈接：

KEGG: mmu:104709

STRING: 10090.ENSMUSP00000052522

UniGene: Mm.234573