Recombinant Mouse Phosphatidylinositide phosphatase SAC2 (Inpp5f), partial

中文名稱：

小鼠Inpp5f重組蛋白
貨號：

CSB-YP805565MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Inpp5f重組蛋白
貨號：

CSB-EP805565MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Inpp5f重組蛋白
貨號：

CSB-EP805565MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Inpp5f重組蛋白
貨號：

CSB-BP805565MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Inpp5f重組蛋白
貨號：

CSB-MP805565MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Inpp5f
Uniprot No.：

Q8CDA1
別名：

Inpp5f; Kiaa0966; Sac2; Phosphatidylinositide phosphatase SAC2; EC 3.1.3.25; Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; hSAC2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries.
基因功能參考文獻：
1. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. PMID: 26908121
2. This study reveals Inpp5f (Sac2) as a novel suppressor of CNS axon repair after spinal cord injury PMID: 26203138
3. Sac2/INPP5F is a PI4P phosphatase that colocalizes with OCRL on endocytic membranes. PMID: 25869668
4. Inpp5f-v3 is specifically expressed in mouse brain, and may function in the development of mouse brain PMID: 21424340
5. A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island. PMID: 15964807
6. Study finds that the Inpp5f_v3 promoter acquires methylation at implantation, which is then lost specifically on the paternally derived allele during the latter stages development, resulting in imprinted activation on the demethylated allele. PMID: 17942418
7. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. PMID: 19875726
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亞細胞定位：

Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
組織特異性：

Highly expressed in brain and hypothalamus, expressed in lung and pancreas, and detected at low levels in liver and heart (at protein level).
數據庫鏈接：

KEGG: mmu:101490

STRING: 10090.ENSMUSP00000045910

UniGene: Mm.490344