Recombinant Mouse Pantothenate kinase 1 (Pank1)

中文名稱：

小鼠Pank1重組蛋白
貨號：

CSB-YP017421MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pank1重組蛋白
貨號：

CSB-EP017421MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pank1重組蛋白
貨號：

CSB-EP017421MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pank1重組蛋白
貨號：

CSB-BP017421MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pank1重組蛋白
貨號：

CSB-MP017421MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pank1
Uniprot No.：

Q8K4K6
別名：

Pank1; Pank; Pantothenate kinase 1; mPank; mPank1; EC 2.7.1.33; Pantothenic acid kinase 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-548
氨基酸序列

MRGRRAPRPG STEVPAAARD ADTLRARAAS PVRGAQLAED VGTPTGGGEE RRGHQLPTAA PRLRESKPQG GSEDRGTADR DLQRGCQSRS PRTAPPVPGM GDRGAQHERA ALQSPGAPEG AAAAVNGLLH NGFHPSAASS RDPPAPRFQL PSELQPQPLF AQHDSPAKKC RLRRRMDSGR KNRPPFPWFG MDIGGTLVKL VYFEPKDITA EEEQEEVENL KSIRKYLTSN TAYGKTGIRD VHLELKNLTM CGRKGNLHFI RFPTCAMHLF IQMGSEKNFS SLHTTLCATG GGAFKFEEDF RMIADLQLHK LDELDCLIQG LLYVDSVGFN GKPECYYFEN PTNPELCQKK PYCLDNPYPM LLVNMGSGVS ILAVYSKDNY KRVTGTSLGG GTFLGLCCLL TGCETFEEAL DMAAKGDSTN VDKLVKDIYG GDYERFGLQG SAVASSFGNM MSKEKRESIS KEDLARATLV TITNNIGSIA RMCALNENID RVVFVGNFLR INMVSMKLLA YAMDFWSKGQ LKALFLEHEG YFGAVGALLE LFKMTDTQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for the hepatic CoA increase during the switch from glucose to fatty acid oxidation that occurs in the fasting state.; Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.; Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
基因功能參考文獻：
1. Pank1 genetic deficiency can be corrected using phosphopantothenate diet replacement therapy. PMID: 26549575
2. The results indicate that Pank1 deficiency drives a whole-body metabolic adaptation that improves aspects of the diabetic phenotype and uncouples hyperglycaemia and hyperinsulinaemia from obesity in leptin-deficient mice. PMID: 24781151
3. p53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1. PMID: 23343762
4. data illustrate the importance of PanK1 and elevated liver CoA levels during fasting to support the metabolic transition from glucose utilization and fatty acid synthesis to gluconeogenesis and fatty acid oxidation PMID: 20559429
亞細胞定位：

[Isoform 1]: Nucleus. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
蛋白家族：

Type II pantothenate kinase family
組織特異性：

[Isoform 1]: Highly expressed in the liver, heart and kidney.; [Isoform 2]: Highly expressed in the liver. Expressed at lower levels in the kidney.
數據庫鏈接：

KEGG: mmu:75735

STRING: 10090.ENSMUSP00000043562

UniGene: Mm.24742