Recombinant Mouse Paired mesoderm homeobox protein 1 (Prrx1)
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中文名稱：小鼠Prrx1重組蛋白
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貨號：CSB-EP018807MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：Prrx1
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Uniprot No.：
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別名：Prrx1; Pmx; Pmx1Paired mesoderm homeobox protein 1; Homeobox protein K-2; Homeobox protein mHox; Paired-related homeobox protein 1; PRX-1
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種屬：Mus musculus (Mouse)
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蛋白長度：Full length protein
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表達區域：1-245
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氨基酸序列MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADESVGEA GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ VPTVN
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
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基因功能參考文獻：
- Postnatal PRX1-expressing stem cells of the calvaria are required for bone regeneration. PMID: 28366454
- These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 molecule fortilin augments the peroxidase PRX1 by protecting it against degradation and inactivation of the enzyme. PMID: 26726832
- PRX-1 has a regulatory role in NF-kappaB nuclear translocation. PMID: 24289074
- The data of this study suggested that Prx1 plays an important role as a key switch for neural cell lineage determination and the maintenance of the self-renewal of adult NSCs at several stages in the adult brain. PMID: 23447615
- These observations suggest that increased Prrx1 expression may promote TGFbeta activity in adipose tissue and thereby contribute to aberrant adipocyte function during obesity. PMID: 23250756
- The two isoforms, Prrx1a and Prrx1b, regulate migration and invasion, respectively, in pancreatic cancer cells PMID: 23355395
- The results suggested that scarless skin-wound healing may require activation of the prx1 limb enhancer, and competence to activate the enhancer is probably a prerequisite for epimorphic regeneration, such as limb regeneration. PMID: 21776009
- These results identify the homeobox protein Prx1 as an obligate mediator of TNF inhibition of Osx and differentiation of osteoblast progenitors. PMID: 20683885
- Generation of Ctgf(+/LacZ) heterozygous null mice and tissue-specific null Ctgf mice, where Ctgf is flanked by lox sequences with mice expressing the Cre recombinase under the control of the paired-related homeobox gene 1 (Prx1) enhancer (Prx1-Cre). PMID: 20534727
- Data show that, during mandibular morphogenesis, Prx1/2 gene products play multiple roles including the cell survival, the region-specific terminal differentiation of Meckelian chondrocytes and osteogenesis. PMID: 19777594
- Results show that Prx I and II are constitutively expressed in the testis and their expression levels are decreased to some extent as the testis develops. PMID: 12163022
- Prx1 is critical for expression of tenascin-C and lung vascularization. PMID: 15117820
- Prx I-/- mice have less reducing activity and are more susceptible to the damage mediated by reactive oxygen species in vivo than wild-type mice. PMID: 16297875
- 3D morphological reconstructions demonstrated that Prx1(-/-)embryos had molar malformations, including cuspal changes and ectopic epithelial projections. PMID: 16998126
- These results suggest that RBMS3, by binding Prx1 mRNA in a sequence-specific manner, controls Prx1 expression and indirectly collagen synthesis. PMID: 17586524
- identification of the two Prx1 target genes, which play a pivotal role in development of liver fibrosis, is a novel finding for liver pathophysiology PMID: 18296734
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亞細胞定位：Nucleus.
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蛋白家族：Paired homeobox family
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組織特異性：Expressed exclusively in mesodermally derived cell types. During embryogenesis, highest levels of expression are found in the mesenchyme and precartilage elements of the face and hind limbs. In the adult, expression is restricted to skeletal muscle, heart
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