Recombinant Mouse PTB domain-containing engulfment adapter protein 1 (Gulp1)

中文名稱：

小鼠Gulp1重組蛋白
貨號：

CSB-YP816983MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Gulp1重組蛋白
貨號：

CSB-EP816983MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Gulp1重組蛋白
貨號：

CSB-EP816983MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gulp1重組蛋白
貨號：

CSB-BP816983MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gulp1重組蛋白
貨號：

CSB-MP816983MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gulp1
Uniprot No.：

Q8K2A1
別名：

Gulp1; Ced6; PTB domain-containing engulfment adapter protein 1; Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-304
氨基酸序列

MNRAFSRKKD KTWMHTPEAL SKHYIPYNAK FLGSTEVEQP KGTEVVRDAV RKLKFARHIK KSEGQKIPKV ELQISIYGVK ILEPKTKEVQ HNCQLHRISF CADDKTDKRI FTFICKDSES NKHLCFVFDS EKCAEEITLT IGQAFDLAYR KFLESGGKDV ETRKQIAGMQ KRIQDLETEN MELKNKVQDL ESRLRTTQVS TSPAHGVTVM SPSTDIFDMI PFSPISHQSP TSARNGTQLP PIPSRSAETK RDLFGAEPFD PFNCGSGDFP PDIQSKLDEM QEGFKMGLTL EGTVFCLDPL DSRC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP. May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6.
基因功能參考文獻：
1. Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism. PMID: 24743597
2. in this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function PMID: 12583998
3. Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton. PMID: 19122200
亞細胞定位：

Cytoplasm.
蛋白家族：

Ced-6 family
組織特異性：

Detected throughout the brain, particularly in Purkinje cells, hippocampal and cortical neurons (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:70676

STRING: 10090.ENSMUSP00000074115

UniGene: Mm.133132